Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1577313..1577998 | Replicon | chromosome |
| Accession | NZ_CP045707 | ||
| Organism | Neisseria gonorrhoeae strain NG250 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | GHB96_RS08060 | Protein ID | WP_003689143.1 |
| Coordinates | 1577816..1577998 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | GHB96_RS08055 | Protein ID | WP_003691454.1 |
| Coordinates | 1577313..1577714 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GHB96_RS08000 (GHB96_08495) | 1572357..1572572 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| GHB96_RS08005 (GHB96_08500) | 1572624..1573115 | - | 492 | WP_047916888.1 | siphovirus Gp157 family protein | - |
| GHB96_RS08010 (GHB96_08505) | 1573112..1573294 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| GHB96_RS08015 (GHB96_08510) | 1573434..1574120 | - | 687 | WP_010357532.1 | hypothetical protein | - |
| GHB96_RS08020 (GHB96_08515) | 1574189..1574350 | - | 162 | WP_003693867.1 | hypothetical protein | - |
| GHB96_RS08025 (GHB96_08520) | 1574347..1574622 | - | 276 | WP_082295533.1 | hypothetical protein | - |
| GHB96_RS08030 (GHB96_08525) | 1574775..1575107 | - | 333 | WP_050155386.1 | hypothetical protein | - |
| GHB96_RS08035 (GHB96_08530) | 1575249..1575536 | - | 288 | WP_215772512.1 | hypothetical protein | - |
| GHB96_RS08040 (GHB96_08535) | 1575533..1576009 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| GHB96_RS08045 (GHB96_08540) | 1576042..1576242 | - | 201 | WP_003704298.1 | hypothetical protein | - |
| GHB96_RS08050 (GHB96_08545) | 1576453..1577214 | + | 762 | WP_012503753.1 | hypothetical protein | - |
| GHB96_RS08055 (GHB96_08550) | 1577313..1577714 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| GHB96_RS08060 (GHB96_08555) | 1577816..1577998 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| GHB96_RS08065 (GHB96_08560) | 1578168..1578986 | - | 819 | WP_012503752.1 | DUF3037 domain-containing protein | - |
| GHB96_RS08070 (GHB96_08565) | 1578983..1579681 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| GHB96_RS08075 (GHB96_08570) | 1579920..1580630 | - | 711 | WP_050161643.1 | helix-turn-helix transcriptional regulator | - |
| GHB96_RS08080 (GHB96_08575) | 1580746..1580934 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| GHB96_RS08085 (GHB96_08580) | 1581014..1581169 | + | 156 | WP_003689578.1 | hypothetical protein | - |
| GHB96_RS08090 (GHB96_08585) | 1581146..1581334 | - | 189 | WP_003691445.1 | hypothetical protein | - |
| GHB96_RS08095 (GHB96_08590) | 1581507..1581734 | + | 228 | WP_003698261.1 | helix-turn-helix domain-containing protein | - |
| GHB96_RS11975 | 1581912..1582340 | + | 429 | WP_252345276.1 | hypothetical protein | - |
| GHB96_RS11980 | 1582435..1582938 | + | 504 | WP_010360005.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1562129..1596419 | 34290 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T142328 WP_003689143.1 NZ_CP045707:c1577998-1577816 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T142328 NZ_CP060668:546320-546805 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT142328 WP_003691454.1 NZ_CP045707:c1577714-1577313 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT142328 NZ_CP060668:546045-546332 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|