Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 2011143..2011746 Replicon chromosome
Accession NZ_CP045706
Organism Sulfolobus sp. E11-6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GFS33_RS10740 Protein ID WP_153425389.1
Coordinates 2011345..2011746 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GFS33_RS10735 Protein ID WP_153425388.1
Coordinates 2011143..2011364 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFS33_RS10715 (GFS33_10715) 2007013..2007822 - 810 WP_153425384.1 N-acyl homoserine lactonase family protein -
GFS33_RS10720 (GFS33_10720) 2007857..2008504 - 648 WP_153425385.1 helix-turn-helix domain-containing protein -
GFS33_RS10725 (GFS33_10725) 2008615..2009769 - 1155 WP_153425386.1 homogentisate 1,2-dioxygenase -
GFS33_RS10730 (GFS33_10730) 2009868..2010899 + 1032 WP_153425387.1 LLM class flavin-dependent oxidoreductase -
GFS33_RS10735 (GFS33_10735) 2011143..2011364 + 222 WP_153425388.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GFS33_RS10740 (GFS33_10740) 2011345..2011746 + 402 WP_153425389.1 PIN domain-containing protein Toxin
GFS33_RS10745 (GFS33_10745) 2011949..2012773 + 825 WP_153422861.1 DMT family transporter -
GFS33_RS10750 (GFS33_10750) 2012735..2014738 - 2004 WP_153425390.1 DEAD/DEAH box helicase -
GFS33_RS10755 (GFS33_10755) 2015197..2016489 - 1293 WP_153422863.1 hydroxyacid-oxoacid transhydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15574.10 Da        Isoelectric Point: 4.7721

>T142325 WP_153425389.1 NZ_CP045706:2011345-2011746 [Sulfolobus sp. E11-6]
VEKAVIDTNIIIYDYIEDSEYHKRAEELLDSLDKWIIPVTVVHELVWFLKGMKLEDKIDDLLAYIRNEKAEVVCDYADNV
RSAIEIVKEEKLPLADYKDIVILSHAIRERLPLITFDRKLSKIAERYGVTIIK

Download         Length: 402 bp

>T142325 NZ_CP060667:45218-46543 [Salmonella enterica]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8467.69 Da        Isoelectric Point: 8.5455

>AT142325 WP_153425388.1 NZ_CP045706:2011143-2011364 [Sulfolobus sp. E11-6]
MERVKVTRNYQITIPASVRSKIGIKEGDVLEVYLNNDEIVLRKVRSERPRIRLGKRLSLEDIEEAIERGESSD

Download         Length: 222 bp

>AT142325 NZ_CP060667:44920-45213 [Salmonella enterica]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References