Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 5619365..5619906 Replicon chromosome
Accession NZ_CP045702
Organism Streptomyces finlayi strain NBSH44

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag F0344_RS25710 Protein ID WP_185301023.1
Coordinates 5619365..5619628 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag F0344_RS25715 Protein ID WP_164493698.1
Coordinates 5619625..5619906 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0344_RS25675 5614460..5614633 - 174 WP_185301020.1 hypothetical protein -
F0344_RS25680 5614781..5615547 + 767 Protein_5059 transposase -
F0344_RS25685 5615632..5616282 - 651 WP_185301021.1 IS5 family transposase -
F0344_RS25690 5616439..5617599 + 1161 WP_185297178.1 IS4 family transposase -
F0344_RS25695 5617936..5618256 - 321 WP_185302891.1 hypothetical protein -
F0344_RS25700 5618860..5618967 - 108 Protein_5063 hypothetical protein -
F0344_RS25705 5618955..5619149 + 195 WP_185301022.1 hypothetical protein -
F0344_RS25710 5619365..5619628 - 264 WP_185301023.1 Txe/YoeB family addiction module toxin Toxin
F0344_RS25715 5619625..5619906 - 282 WP_164493698.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F0344_RS25720 5620870..5621103 + 234 WP_185301024.1 type II toxin-antitoxin system VapB family antitoxin -
F0344_RS25725 5621100..5621507 + 408 WP_185301025.1 PIN domain nuclease -
F0344_RS25730 5621960..5622334 + 375 WP_185301026.1 metalloregulator ArsR/SmtB family transcription factor -
F0344_RS25735 5622458..5623210 - 753 WP_185301027.1 GntR family transcriptional regulator -
F0344_RS25740 5623508..5624632 + 1125 WP_185302892.1 extracellular solute-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5612901..5631803 18902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10416.78 Da        Isoelectric Point: 8.0720

>T142324 WP_185301023.1 NZ_CP045702:c5619628-5619365 [Streptomyces finlayi]
VKVLFVDDGWNDYLWWQGNDRKILKRINQLIADIDRGGHEGIGKPEPLRNDLSGYWSRRINSEHRLVYRIDENAIIHVVA
CRFHYER

Download         Length: 264 bp

>T142324 NZ_CP060667:18030-18335 [Salmonella enterica]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10156.38 Da        Isoelectric Point: 4.2158

>AT142324 WP_164493698.1 NZ_CP045702:c5619906-5619625 [Streptomyces finlayi]
MKTMSVTELRAGIADALDAVENDAEELVITRTGHEPMVVVSLAEYEALKETDYLLRSPAMAERLRRSIEQDRAGQGALRE
LVDPDDEAGRGAA

Download         Length: 282 bp

>AT142324 NZ_CP060667:17810-18028 [Salmonella enterica]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References