Detailed information of TA system TA142322

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 5361692..5362256
• Replicon: chromosome
• Accession: NZ_CP045702
• Organism: Streptomyces finlayi strain NBSH44

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: F0344_RS24670
• Protein ID: WP_185302873.1
• Coordinates: 5361906..5362256 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: F0344_RS24665
• Protein ID: WP_185300859.1
• Coordinates: 5361692..5361916 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0344_RS24640	5357463..5357693	+	231	WP_185300855.1	hypothetical protein	-
F0344_RS24645	5357801..5357950	+	150	Protein_4859	allantoicase	-
F0344_RS24650	5357993..5358382	+	390	WP_185300856.1	VOC family protein	-
F0344_RS24655	5358447..5361023	-	2577	WP_185300857.1	aminopeptidase N	-
F0344_RS24660	5361136..5361633	+	498	WP_185300858.1	DUF1203 domain-containing protein	-
F0344_RS24665	5361692..5361916	+	225	WP_185300859.1	ribbon-helix-helix domain-containing protein	Antitoxin
F0344_RS24670	5361906..5362256	+	351	WP_185302873.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
F0344_RS24675	5362315..5363343	-	1029	WP_185300860.1	aspartate-semialdehyde dehydrogenase	-
F0344_RS24680	5363511..5364108	+	598	Protein_4866	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-116)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12696.66 Da
• Isoelectric Point: 11.3562

>T142322 WP_185302873.1 NZ_CP045702:5361906-5362256 [Streptomyces finlayi]
MMRRGDIHLVDLEPAKGSEANKVRPAVIVSNNAANQSVESNGRGVITVLPLTSNTARVLTFQALLTSAESGLPRDSKVQC
EQVRAVSLERVLKRIGTVPRQRMTEIDTALRRHLAL

Nucleotide

• Length: 351 bp

>T142322 NZ_CP060666:4632323-4632691 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8118.84 Da
• Isoelectric Point: 3.7210

>AT142322 WP_185300859.1 NZ_CP045702:5361692-5361916 [Streptomyces finlayi]
MKISVSLPQEDVTFVDEYAAKTEADSRSAVIHAAIELLREAGLEAEYTEAFEEWDASEDAVLWDRTVGDGIADA

Nucleotide

• Length: 225 bp

>AT142322 NZ_CP060666:4632105-4632326 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA