Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 3262523..3263090 Replicon chromosome
Accession NZ_CP045702
Organism Streptomyces finlayi strain NBSH44

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag F0344_RS14970 Protein ID WP_185299263.1
Coordinates 3262830..3263090 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F0344_RS14965 Protein ID WP_185299262.1
Coordinates 3262523..3262825 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0344_RS14935 3257976..3258163 + 188 Protein_2962 phosphatidate cytidylyltransferase -
F0344_RS14940 3258227..3258628 + 402 WP_185299257.1 PPOX class F420-dependent oxidoreductase -
F0344_RS14945 3258639..3259640 - 1002 WP_185299258.1 WD40 repeat domain-containing protein -
F0344_RS14950 3259699..3260382 + 684 WP_185299259.1 hypothetical protein -
F0344_RS14955 3260609..3261241 - 633 WP_185299260.1 TetR/AcrR family transcriptional regulator -
F0344_RS14960 3261374..3262357 - 984 WP_185299261.1 hypothetical protein -
F0344_RS14965 3262523..3262825 + 303 WP_185299262.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F0344_RS14970 3262830..3263090 + 261 WP_185299263.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0344_RS14975 3263131..3263550 - 420 WP_185299264.1 hypothetical protein -
F0344_RS14980 3263668..3264441 + 774 WP_185302698.1 helix-turn-helix domain-containing protein -
F0344_RS14985 3264438..3264686 + 249 WP_185299265.1 DUF397 domain-containing protein -
F0344_RS14990 3264716..3265147 + 432 WP_185299266.1 protease inhibitor -
F0344_RS14995 3265253..3265744 - 492 WP_185302699.1 hypothetical protein -
F0344_RS15000 3265816..3266586 + 771 WP_185299267.1 SDR family oxidoreductase -
F0344_RS15005 3266852..3266941 - 90 Protein_2976 transposase -
F0344_RS15010 3266929..3267084 + 156 WP_185299268.1 hypothetical protein -
F0344_RS15015 3267087..3268061 + 975 WP_185299269.1 prolyl aminopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(16-78)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9824.32 Da        Isoelectric Point: 10.0888

>T142321 WP_185299263.1 NZ_CP045702:3262830-3263090 [Streptomyces finlayi]
VGYVTQFTAHAQRDLLKIPLQDARRLLVRFAELQKAMDSGDLAAFDIKPLQGHHARWRLRVGDYHAVYTVEDGRLIIWVM
GGHRSA

Download         Length: 261 bp

>T142321 NZ_CP060666:4522251-4522736 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11565.95 Da        Isoelectric Point: 4.2707

>AT142321 WP_185299262.1 NZ_CP045702:3262523-3262825 [Streptomyces finlayi]
MYICYVSYMSEPVVESMAEVRRHLADVIDRARRDDTPTIITRRGKSEVVVVDIDEYRRLCEAAERLEDEWLNRMADEAES
EGTEESVSLEEMAALLRSAH

Download         Length: 303 bp

>AT142321 NZ_CP060666:4521976-4522263 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References