Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2598663..2599188 Replicon chromosome
Accession NZ_CP045702
Organism Streptomyces finlayi strain NBSH44

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag F0344_RS11680 Protein ID WP_185298715.1
Coordinates 2598925..2599188 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F0344_RS11675 Protein ID WP_185298714.1
Coordinates 2598663..2598932 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0344_RS11650 2593896..2594537 - 642 WP_185298709.1 response regulator transcription factor -
F0344_RS11655 2594534..2595781 - 1248 WP_185298710.1 sensor histidine kinase -
F0344_RS11660 2595948..2597027 + 1080 WP_185298711.1 ABC transporter permease -
F0344_RS11665 2597024..2597704 + 681 WP_185298712.1 ABC transporter ATP-binding protein -
F0344_RS11670 2597838..2598368 + 531 WP_185298713.1 Uma2 family endonuclease -
F0344_RS11675 2598663..2598932 + 270 WP_185298714.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F0344_RS11680 2598925..2599188 + 264 WP_185298715.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0344_RS11685 2599418..2599759 - 342 WP_185298716.1 hypothetical protein -
F0344_RS11690 2600073..2601467 - 1395 WP_185298717.1 SWIM zinc finger family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10084.58 Da        Isoelectric Point: 9.5290

>T142319 WP_185298715.1 NZ_CP045702:2598925-2599188 [Streptomyces finlayi]
VSEYRTVFRPEAKAELRKIPRDMALRILAKLTELESDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHIGH
RSTVYDT

Download         Length: 264 bp

>T142319 NZ_CP060666:c4131063-4130752 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10337.85 Da        Isoelectric Point: 5.2647

>AT142319 WP_185298714.1 NZ_CP045702:2598663-2598932 [Streptomyces finlayi]
MTQPMPRKSIRDVRAHLAEVVERAERDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAAGIPIEDI
MRETLARSE

Download         Length: 270 bp

>AT142319 NZ_CP060666:c4130751-4130461 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References