Detailed information of TA system TA142317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4406580..4407143
• Replicon: chromosome
• Accession: NZ_CP045701
• Organism: Pseudomonas brassicacearum strain S-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GFU70_RS18630
• Protein ID: WP_116641690.1
• Coordinates: 4406880..4407143 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A5Q0S9F9
• Locus tag: GFU70_RS18625
• Protein ID: WP_058542883.1
• Coordinates: 4406580..4406867 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GFU70_RS18595	4401877..4402233	-	357	WP_153389157.1	IS66 family insertion sequence element accessory protein TnpB	-
GFU70_RS18600	4402324..4402647	-	324	Protein_3685	integrase	-
GFU70_RS18605	4402981..4403622	-	642	WP_153388579.1	hypothetical protein	-
GFU70_RS18610	4403619..4404425	-	807	WP_153388580.1	DUF4276 family protein	-
GFU70_RS18615	4405202..4405510	+	309	WP_038858737.1	putative addiction module antidote protein	-
GFU70_RS18620	4405639..4405911	-	273	WP_003203821.1	hypothetical protein	-
GFU70_RS18625	4406580..4406867	+	288	WP_058542883.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GFU70_RS18630	4406880..4407143	+	264	WP_116641690.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GFU70_RS18635	4407530..4407739	+	210	WP_058542881.1	hypothetical protein	-
GFU70_RS18640	4408475..4408990	-	516	WP_153388581.1	lysis system i-spanin subunit Rz	-
GFU70_RS18645	4408987..4409412	-	426	WP_153388582.1	cell wall hydrolase	-
GFU70_RS18650	4409473..4409934	-	462	WP_153388583.1	hypothetical protein	-
GFU70_RS18655	4410633..4410992	-	360	Protein_3696	tail fiber domain-containing protein	-
GFU70_RS18660	4411006..4411680	-	675	WP_153388584.1	hypothetical protein	-
GFU70_RS18665	4411680..4412003	-	324	WP_153388585.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4393906..4449567	55661

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-77)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9909.59 Da
• Isoelectric Point: 10.7150

>T142317 WP_116641690.1 NZ_CP045701:4406880-4407143 [Pseudomonas brassicacearum]
VGSEALKELRKLDGAIRLQFLKKLQQRQTGPRVPGDALHGMKDCYKIKLRGAGYRLVYRVEDERIVILVLAVGKRERSSV
YEQAGNR

Nucleotide

• Length: 264 bp

>T142317 NZ_CP060666:c3714726-3714442 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10177.60 Da
• Isoelectric Point: 4.4341

>AT142317 WP_058542883.1 NZ_CP045701:4406580-4406867 [Pseudomonas brassicacearum]
MQNILADVAVSVSELKKNPSSVLSGANGLPVAVLNHNRVVGYMVPANVYEAMVERLDELELVHLAKARLDANETPVRVSL
DDLIGEAEADIANGR

Nucleotide

• Length: 288 bp

>AT142317 NZ_CP060666:c3714958-3714716 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A5Q0S9F9