Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 893299..894860 Replicon chromosome
Accession NZ_CP045700
Organism Vibrio sp. SM1977

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GFB47_RS15975 Protein ID WP_153448955.1
Coordinates 893541..894860 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GFB47_RS15970 Protein ID WP_153448954.1
Coordinates 893299..893541 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFB47_RS15945 888631..890373 - 1743 WP_153448950.1 urease subunit alpha -
GFB47_RS15950 890561..890908 - 348 WP_153448951.1 urease subunit beta -
GFB47_RS15955 890918..891220 - 303 WP_153449046.1 urease subunit gamma -
GFB47_RS15960 891243..892148 - 906 WP_153448952.1 urease accessory protein UreD -
GFB47_RS15965 892253..893083 - 831 WP_153448953.1 SDR family oxidoreductase -
GFB47_RS15970 893299..893541 + 243 WP_153448954.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
GFB47_RS15975 893541..894860 + 1320 WP_153448955.1 type II toxin-antitoxin system HipA family toxin Toxin
GFB47_RS15980 894916..895611 - 696 WP_153448956.1 urea ABC transporter ATP-binding subunit UrtE -
GFB47_RS15985 895614..896477 - 864 WP_153448957.1 urea ABC transporter ATP-binding protein UrtD -
GFB47_RS15990 896474..897703 - 1230 WP_153448958.1 urea ABC transporter permease subunit UrtC -
GFB47_RS15995 897713..899356 - 1644 WP_153449047.1 urea ABC transporter permease subunit UrtB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-64)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49382.21 Da        Isoelectric Point: 8.5528

>T142314 WP_153448955.1 NZ_CP045700:893541-894860 [Vibrio sp. SM1977]
MASLIAYMNGERVGELIKLTNGAHQFQYDKTWIESSLGRPLSLSLPLQYPKITTDSVINYFDNLLPDLPEIRARIVARYQ
AKSLQTFDLLKEVGKDSVGAISLLTNNETPHPKQLNYEVLSQTRLKQVLSAYQSNIPLGMLEDQADFRISVAGAQEKTAL
LKINDQWCIPQAATPTTHIIKLPIGKIQQPNAVLDMTDSVENEYLCLQLAQALGFQVPTVEILQVENIKALAVERFDRRW
SKDKTWLLRLPQEDMCQAFGLPSAIKYESDGGPGITAIMQLLMGSSHSLQDRDTFMRFQVFQWIIGATDGHAKNFSIFIN
TKGTYHLTPFYDILSAYPVLNGAGLNIRALKLAMGLKATKGKKYPLNKIYPRHFLDTAKEVGFDPHRMQAILDEMMTAYP
KAIEHVVQALPQGFPQHITDAIVVNSLKMLEKLNLRNIK

Download         Length: 1320 bp

>T142314 NZ_CP060666:3244333-3244590 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9256.63 Da        Isoelectric Point: 7.2024

>AT142314 WP_153448954.1 NZ_CP045700:893299-893541 [Vibrio sp. SM1977]
MIYNPKQLANQLKLIRTQRDLTQSELAKKVGIKQSTLSSFETHPETTQLQTVFKIIQALEVDFELHKKQLSTVAVTDEEW

Download         Length: 243 bp

>AT142314 NZ_CP060666:c3244508-3244176 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References