Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4717856..4718372 Replicon chromosome
Accession NZ_CP045694
Organism Klebsiella pneumoniae strain TK421

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag GHA50_RS24080 Protein ID WP_009309309.1
Coordinates 4717856..4718140 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GHA50_RS24085 Protein ID WP_002886901.1
Coordinates 4718130..4718372 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHA50_RS24060 4713340..4713648 - 309 WP_020079792.1 PTS sugar transporter subunit IIB -
GHA50_RS27270 4713733..4713906 + 174 WP_032412860.1 hypothetical protein -
GHA50_RS24065 4713909..4714652 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GHA50_RS24070 4715009..4717147 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
GHA50_RS24075 4717388..4717852 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GHA50_RS24080 4717856..4718140 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GHA50_RS24085 4718130..4718372 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GHA50_RS24090 4718450..4720360 - 1911 WP_023280782.1 BglG family transcription antiterminator -
GHA50_RS24095 4720383..4721537 - 1155 WP_023280781.1 lactonase family protein -
GHA50_RS24100 4721604..4722344 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T142303 WP_009309309.1 NZ_CP045694:c4718140-4717856 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T142303 NZ_CP060645:1641092-1641427 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAAGTTTTCCGAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT142303 WP_002886901.1 NZ_CP045694:c4718372-4718130 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT142303 NZ_CP060645:1640815-1641102 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References