Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 920257..920914 Replicon chromosome
Accession NZ_CP045694
Organism Klebsiella pneumoniae strain TK421

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GHA50_RS06125 Protein ID WP_002916310.1
Coordinates 920504..920914 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GHA50_RS06120 Protein ID WP_002916312.1
Coordinates 920257..920523 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHA50_RS06095 915413..916846 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
GHA50_RS06100 916965..917693 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GHA50_RS06105 917743..918054 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GHA50_RS06110 918218..918877 + 660 WP_040222708.1 hemolysin III family protein -
GHA50_RS06115 919028..920011 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GHA50_RS06120 920257..920523 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GHA50_RS06125 920504..920914 + 411 WP_002916310.1 protein YgfX Toxin
GHA50_RS06130 920921..921442 - 522 WP_004144730.1 flavodoxin FldB -
GHA50_RS06135 921543..922439 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GHA50_RS06140 922462..923175 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GHA50_RS06145 923181..924914 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T142290 WP_002916310.1 NZ_CP045694:920504-920914 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T142290 NZ_CP060595:c282628-282281 [Pseudomonas monteilii]
ATGAGTAACCCCAGCATACGCTTCACCCATTCCGCCTCTCAGAGCATTGAAGATCAAGTGCACCATCTGGCCGTCTATCA
CGGTACCGCAGCGGCACTTGAGAAAATCACCACACTGGTCGACACGATTGAGCACCGGCTGGCTGCCGCGCCTGTAGGCT
ACCCGGTCAGCCCACAGGCGAGCGGGCTGGGCGTCATGCAGTATCGTGAACTGAATATCGAAGGGTACAGGGTGTTCTAC
GAAGTGATCGAAACCGACAATGCCATTGCCGTGGAGTTGGTGCTCAGGCAAAAGCAGAGTGTTGAACAGGCATTGATTCG
GTATTGCCTGATTTACCCATTACCTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT142290 WP_002916312.1 NZ_CP045694:920257-920523 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142290 NZ_CP060595:c282887-282639 [Pseudomonas monteilii]
ATGCGAGTCGAAACGATCAGCTACCTGAAACGCCACGCTGCTGACCTGGATCTGGAAGAACCCATGGTCGTGACACAGAA
CGGTGTGCCTGCTTATGTGGTCGAGTCCTACGCGGATCGCAAGCAACGGGATGAAGCCATAGCCTTGGTGAAACTGCTCG
CCATCGGTTCCCGTGAGTATGCTCAGGGCAAACACAGCTCTGCCGAAGACCTCAAGGCTCGCCTTCTCAAGAAATTTTCT
GAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References