Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 5840..6365 Replicon plasmid pWSD411_5
Accession NZ_CP045678
Organism Klebsiella pneumoniae strain WSD411

Toxin (Protein)


Gene name ccdB Uniprot ID D4HQE7
Locus tag F8D37_RS27770 Protein ID WP_013023785.1
Coordinates 5840..6145 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1D8K3R4
Locus tag F8D37_RS27775 Protein ID WP_006788213.1
Coordinates 6147..6365 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8D37_RS27740 1543..2169 + 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -
F8D37_RS29075 2166..2468 + 303 WP_071571079.1 hypothetical protein -
F8D37_RS27750 2916..3710 - 795 WP_004197635.1 site-specific integrase -
F8D37_RS27755 3908..4924 - 1017 WP_017899884.1 hypothetical protein -
F8D37_RS27760 4935..5249 - 315 WP_053389906.1 hypothetical protein -
F8D37_RS27765 5276..5671 - 396 WP_017899885.1 hypothetical protein -
F8D37_RS27770 5840..6145 - 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB Toxin
F8D37_RS27775 6147..6365 - 219 WP_006788213.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
F8D37_RS27780 6946..7515 + 570 WP_016162066.1 hypothetical protein -
F8D37_RS27785 7656..8684 + 1029 WP_001568023.1 Abi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94887 94887


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(12-42)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T142281 WP_013023785.1 NZ_CP045678:c6145-5840 [Klebsiella pneumoniae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T142281 NZ_CP060587:771865-772284 [Aeromicrobium sp. zg-629]
GTGATCGTGCTCGACACGAACGTCATCTCGGAGATCTTCCGTCCACAACCTGAGCCGCGCGTGCTCGCGTGGCTCGAGTC
GCTCACCGATGACGTCGCCATCACCTCGATCACGCTTGCGGAGCTACTCGCCGAAGTTCGCGGGCTCCCGGAGGGGCGAC
GCAAGACGGATCTCTCGGCGGCGATCCATGCCGCGATCCAGCCGTACCGGGACACGCGTTCGCTGCTGGCCTTCGACGCG
GATGCTGCTGATGAGTACGCCGAGGTGTTCGTGTTGCGCGAGCGCGCCGGGCTGCCGATCAGCATGGCCGATGCCCAGAT
TGCCGCGATCTGCCGCGCGAATCGGGCGGTGTGCGCCACCCGGAACGTGAAGGACTTCGACGCCACCGGCGTGGAGGTCG
TCAACCCTTGGGGTGGGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT142281 WP_006788213.1 NZ_CP045678:c6365-6147 [Klebsiella pneumoniae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT142281 NZ_CP060587:771635-771868 [Aeromicrobium sp. zg-629]
ATGGCGTCCATCATTGTCAGAGGGCTCGATGATTCGGTGAAGCAGCGGCTCGCCGCGCAGGCCGAGGAGCACGGCCGGTC
GATGGAGGCCGAGGTGCGTGACATCCTCACGCGGGCGGCGTCGCGGCCCCATGTCGGGCTCGCGCTCCTGGAGGCCGCTC
GTGCCGTCGGGGGCGTGGAGGATCTTGCGATTCCTGAGCGCTCCGACGCGGCTCGCGGGGTGGACTTCGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8K3R4

References