Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 57770..58413 Replicon plasmid pWSD411_3
Accession NZ_CP045676
Organism Klebsiella pneumoniae strain WSD411

Toxin (Protein)


Gene name vagD Uniprot ID A0A7D6UII7
Locus tag F8D37_RS26555 Protein ID WP_032425563.1
Coordinates 57770..58186 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID R4IT22
Locus tag F8D37_RS26560 Protein ID WP_016338373.1
Coordinates 58183..58413 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8D37_RS26540 52818..54926 - 2109 WP_016338368.1 peptidase domain-containing ABC transporter -
F8D37_RS26545 54916..56193 - 1278 WP_016338369.1 HlyD family secretion protein -
F8D37_RS26550 56852..57729 + 878 Protein_64 restriction endonuclease -
F8D37_RS26555 57770..58186 - 417 WP_032425563.1 type II toxin-antitoxin system VapC family toxin Toxin
F8D37_RS26560 58183..58413 - 231 WP_016338373.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F8D37_RS26565 58631..59545 - 915 WP_126834912.1 Abi family protein -
F8D37_RS26570 59838..60791 - 954 WP_109549184.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
F8D37_RS26575 61395..61601 + 207 WP_004153649.1 hypothetical protein -
F8D37_RS26580 61647..61955 + 309 WP_004152336.1 hypothetical protein -
F8D37_RS26585 61983..62312 + 330 WP_004152337.1 hypothetical protein -
F8D37_RS26590 62338..62736 + 399 WP_004171440.1 hypothetical protein -
F8D37_RS26595 62743..63075 + 333 WP_004152339.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..146858 146858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 20475.56 Da        Isoelectric Point: 5.5500

>T142280 WP_032425563.1 NZ_CP045676:c58186-57770 [Klebsiella pneumoniae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 417 bp

>T142280 NZ_CP045676:c58186-57770 [Klebsiella pneumoniae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT142280 WP_016338373.1 NZ_CP045676:c58413-58183 [Klebsiella pneumoniae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT142280 NZ_CP045676:c58413-58183 [Klebsiella pneumoniae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6UII7

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LN61

References