Detailed information of TA system TA142275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 951485..952014
• Replicon: chromosome
• Accession: NZ_CP045670
• Organism: Treponema pedis strain T3552B

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DYQ05_RS04135
• Protein ID: WP_038096190.1
• Coordinates: 951760..952014 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S5ZYZ1
• Locus tag: DYQ05_RS04130
• Protein ID: WP_020964673.1
• Coordinates: 951485..951760 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYQ05_RS04100	947507..947854	+	348	WP_024466099.1	HNH endonuclease	-
DYQ05_RS04105	948037..948213	+	177	WP_187289356.1	hypothetical protein	-
DYQ05_RS04110	948215..948580	+	366	WP_029408977.1	hypothetical protein	-
DYQ05_RS04115	949228..950517	+	1290	WP_020964670.1	ATP-binding protein	-
DYQ05_RS04120	950544..950828	+	285	WP_020964671.1	hypothetical protein	-
DYQ05_RS04125	950881..951129	+	249	WP_020964672.1	hypothetical protein	-
DYQ05_RS04130	951485..951760	+	276	WP_020964673.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DYQ05_RS04135	951760..952014	+	255	WP_038096190.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DYQ05_RS04140	952143..952454	+	312	WP_206183898.1	HEAT repeat domain-containing protein	-
DYQ05_RS04145	952461..952926	+	466	Protein_815	hypothetical protein	-
DYQ05_RS04150	953260..954980	+	1721	Protein_816	ABC transporter ATP-binding protein	-
DYQ05_RS04155	955068..955523	-	456	WP_020964678.1	helix-turn-helix transcriptional regulator	-
DYQ05_RS04160	955715..955855	+	141	WP_187289357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-76)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9964.74 Da
• Isoelectric Point: 9.9845

>T142275 WP_038096190.1 NZ_CP045670:951760-952014 [Treponema pedis]
MSYKLKKTHQFKASYKLAKKRGLDVSLLEDIVEKLRTDKPLEAKYRNHELAGKFKGVWECHIQPDWLLLYYKDKNILVLT
LVDT

Nucleotide

• Length: 255 bp

>T142275 NZ_CP060584:757027-757236 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAACATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10232.64 Da
• Isoelectric Point: 4.3575

>AT142275 WP_020964673.1 NZ_CP045670:951485-951760 [Treponema pedis]
MATVILQTRVDVETKKEAESLFTSLGLDITTAIRLFLKQAINQQKIPFDIVPPQEIFSEYTLSAIEEAKKISSDSSVKSY
SSARELFEDCE

Nucleotide

• Length: 276 bp

>AT142275 NZ_CP060584:756722-757015 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: S5ZYZ1