Detailed information of TA system TA142271

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4802152..4802668
• Replicon: chromosome
• Accession: NZ_CP045661
• Organism: Klebsiella pneumoniae strain SMU18037509

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GFJ44_RS22985
• Protein ID: WP_023317444.1
• Coordinates: 4802152..4802436 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: GFJ44_RS22990
• Protein ID: WP_002886901.1
• Coordinates: 4802426..4802668 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GFJ44_RS22965	4797547..4797855	-	309	WP_012737232.1	PTS sugar transporter subunit IIB	-
GFJ44_RS26870	4797940..4798113	+	174	WP_032408826.1	hypothetical protein	-
GFJ44_RS22970	4798116..4798859	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
GFJ44_RS22975	4799216..4801354	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
GFJ44_RS22980	4801684..4802148	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
GFJ44_RS22985	4802152..4802436	-	285	WP_023317444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GFJ44_RS22990	4802426..4802668	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GFJ44_RS22995	4802746..4804656	-	1911	WP_004152270.1	BglG family transcription antiterminator	-
GFJ44_RS23000	4804679..4805833	-	1155	WP_002886900.1	lactonase family protein	-
GFJ44_RS23005	4805900..4806640	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11151.99 Da
• Isoelectric Point: 10.3787

>T142271 WP_023317444.1 NZ_CP045661:c4802436-4802152 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T142271 NZ_CP060584:374308-374574 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT142271 WP_002886901.1 NZ_CP045661:c4802668-4802426 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT142271 NZ_CP060584:374051-374308 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0