Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4072194..4072813 Replicon chromosome
Accession NZ_CP045661
Organism Klebsiella pneumoniae strain SMU18037509

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GFJ44_RS19580 Protein ID WP_002892050.1
Coordinates 4072595..4072813 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GFJ44_RS19575 Protein ID WP_002892066.1
Coordinates 4072194..4072568 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFJ44_RS19565 4067346..4068539 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GFJ44_RS19570 4068562..4071708 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GFJ44_RS19575 4072194..4072568 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GFJ44_RS19580 4072595..4072813 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GFJ44_RS19585 4072972..4073538 + 567 WP_002892030.1 maltose O-acetyltransferase -
GFJ44_RS26815 4073510..4073650 - 141 WP_004147370.1 hypothetical protein -
GFJ44_RS19590 4073671..4074141 + 471 WP_002892026.1 YlaC family protein -
GFJ44_RS19595 4074116..4075567 - 1452 WP_032436946.1 PLP-dependent aminotransferase family protein -
GFJ44_RS19600 4075668..4076366 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
GFJ44_RS19605 4076363..4076503 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GFJ44_RS19610 4076503..4076766 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T142269 WP_002892050.1 NZ_CP045661:4072595-4072813 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T142269 NZ_CP060528:984450-984632 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAACGCTATGGTTACTGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTTAAAAACAGTAAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT142269 WP_002892066.1 NZ_CP045661:4072194-4072568 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT142269 NZ_CP060528:983827-984426 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGACAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGTAAAGAACAAGCACCAGTGTTTGATGAACTTAAGAAAAATGTGG
AAAATCATGCAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGTCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGCAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTAAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References