Detailed information of TA system TA142268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2668353..2669941
• Replicon: chromosome
• Accession: NZ_CP045661
• Organism: Klebsiella pneumoniae strain SMU18037509

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GFJ44_RS12795
• Protein ID: WP_032436337.1
• Coordinates: 2668353..2669675 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: GFJ44_RS12800
• Protein ID: WP_002904790.1
• Coordinates: 2669675..2669941 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GFJ44_RS12780	2663410..2665911	+	2502	WP_032436339.1	fimbrial biogenesis outer membrane usher protein	-
GFJ44_RS12785	2665899..2666903	+	1005	WP_032436338.1	type 1 fimbrial protein	-
GFJ44_RS12790	2667044..2668336	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
GFJ44_RS12795	2668353..2669675	-	1323	WP_032436337.1	type II toxin-antitoxin system HipA family toxin	Toxin
GFJ44_RS12800	2669675..2669941	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
GFJ44_RS12805	2670328..2670654	-	327	WP_032436336.1	hydroxyisourate hydrolase	-
GFJ44_RS12810	2670651..2671151	-	501	WP_032436335.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
GFJ44_RS12815	2671129..2672508	-	1380	Protein_2539	purine permease	-
GFJ44_RS12820	2672854..2674008	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
GFJ44_RS12825	2673989..2674912	-	924	WP_032436334.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49106.39 Da
• Isoelectric Point: 7.5617

>T142268 WP_032436337.1 NZ_CP045661:c2669675-2668353 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T142268 NZ_CP060528:821633-821995 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT142268 WP_002904790.1 NZ_CP045661:c2669941-2669675 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT142268 NZ_CP060528:821466-821636 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8