Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 813858..814515 Replicon chromosome
Accession NZ_CP045661
Organism Klebsiella pneumoniae strain SMU18037509

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GFJ44_RS03990 Protein ID WP_002916310.1
Coordinates 814105..814515 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GFJ44_RS03985 Protein ID WP_002916312.1
Coordinates 813858..814124 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFJ44_RS03960 809066..810499 - 1434 WP_153517841.1 6-phospho-beta-glucosidase -
GFJ44_RS03965 810618..811346 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GFJ44_RS03970 811396..811707 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GFJ44_RS03975 811871..812530 + 660 WP_002916317.1 hemolysin III family protein -
GFJ44_RS03980 812629..813612 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
GFJ44_RS03985 813858..814124 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GFJ44_RS03990 814105..814515 + 411 WP_002916310.1 protein YgfX Toxin
GFJ44_RS03995 814522..815043 - 522 WP_004144730.1 flavodoxin FldB -
GFJ44_RS04000 815144..816040 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GFJ44_RS04005 816063..816776 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GFJ44_RS04010 816782..818515 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T142259 WP_002916310.1 NZ_CP045661:814105-814515 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T142259 NZ_CP060513:50117-50422 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT142259 WP_002916312.1 NZ_CP045661:813858-814124 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142259 NZ_CP060513:49897-50115 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References