Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 866137..866666 Replicon chromosome
Accession NZ_CP045648
Organism Staphylococcus epidermidis strain IRL01

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag GFV05_RS04230 Protein ID WP_001829891.1
Coordinates 866304..866666 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag GFV05_RS04225 Protein ID WP_001829931.1
Coordinates 866137..866307 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFV05_RS04200 861962..862441 + 480 WP_001829909.1 PH domain-containing protein -
GFV05_RS04205 862434..863939 + 1506 WP_001829976.1 PH domain-containing protein -
GFV05_RS04210 863926..864435 + 510 WP_001829888.1 PH domain-containing protein -
GFV05_RS04215 864483..864836 + 354 WP_001829915.1 holo-ACP synthase -
GFV05_RS04220 864902..866050 + 1149 WP_002468951.1 alanine racemase -
GFV05_RS04225 866137..866307 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
GFV05_RS04230 866304..866666 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GFV05_RS04235 867160..868332 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
GFV05_RS04240 868443..869345 + 903 Protein_790 PP2C family protein-serine/threonine phosphatase -
GFV05_RS04245 869445..869771 + 327 WP_001829952.1 anti-sigma factor antagonist -
GFV05_RS04250 869773..870252 + 480 WP_001829903.1 anti-sigma B factor RsbW -
GFV05_RS04255 870227..870997 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 867160..868332 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T142253 WP_001829891.1 NZ_CP045648:866304-866666 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T142253 NZ_CP060505:2222349-2222738 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGATCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT142253 WP_001829931.1 NZ_CP045648:866137-866307 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT142253 NZ_CP060505:2222085-2222342 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References