Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 854954..855463 Replicon chromosome
Accession NZ_CP045648
Organism Staphylococcus epidermidis strain IRL01

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag GFV05_RS04170 Protein ID WP_001829980.1
Coordinates 855254..855463 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag GFV05_RS04165 Protein ID WP_001829893.1
Coordinates 854954..855247 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFV05_RS04140 849962..850750 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
GFV05_RS04145 850756..851394 + 639 WP_154436024.1 thiamine phosphate synthase -
GFV05_RS04150 851483..852355 + 873 WP_002458703.1 membrane protein insertase YidC -
GFV05_RS04155 852461..853114 - 654 WP_001829983.1 HD domain-containing protein -
GFV05_RS04160 853296..854780 - 1485 WP_002457116.1 cardiolipin synthase -
GFV05_RS04165 854954..855247 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
GFV05_RS04170 855254..855463 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
GFV05_RS04175 855606..855743 + 138 WP_001829949.1 hypothetical protein -
GFV05_RS04180 855843..857054 - 1212 WP_001829910.1 rod shape-determining protein RodA -
GFV05_RS04185 857445..858518 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
GFV05_RS04190 858530..859885 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T142252 WP_001829980.1 NZ_CP045648:855254-855463 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T142252 NZ_CP060504:1695843-1696232 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGATCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT142252 WP_001829893.1 NZ_CP045648:854954-855247 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT142252 NZ_CP060504:1695579-1695836 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References