Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3710249..3710902 Replicon chromosome
Accession NZ_CP045645
Organism Acinetobacter baumannii strain XH1056

Toxin (Protein)


Gene name cptA Uniprot ID A0A5N0FZY3
Locus tag GFM36_RS17990 Protein ID WP_000607074.1
Coordinates 3710249..3710638 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag GFM36_RS17995 Protein ID WP_001288210.1
Coordinates 3710645..3710902 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFM36_RS17975 (GFM36_18050) 3705367..3707562 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
GFM36_RS17980 (GFM36_18055) 3707750..3708316 - 567 WP_000651536.1 rhombosortase -
GFM36_RS17985 (GFM36_18060) 3708394..3709479 - 1086 WP_000049106.1 hypothetical protein -
GFM36_RS17990 (GFM36_18065) 3710249..3710638 - 390 WP_000607074.1 membrane protein Toxin
GFM36_RS17995 (GFM36_18070) 3710645..3710902 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
GFM36_RS18000 (GFM36_18075) 3711090..3712262 + 1173 WP_001190545.1 acyl-CoA dehydrogenase family protein -
GFM36_RS18005 (GFM36_18080) 3712312..3713802 - 1491 WP_000415136.1 NAD(P)/FAD-dependent oxidoreductase -
GFM36_RS18010 (GFM36_18085) 3713984..3714361 - 378 WP_001216380.1 50S ribosomal protein L17 -
GFM36_RS18015 (GFM36_18090) 3714380..3715387 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15621.89 Da        Isoelectric Point: 10.3890

>T142249 WP_000607074.1 NZ_CP045645:c3710638-3710249 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T142249 NZ_CP060491:2042872-2043060 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT142249 WP_001288210.1 NZ_CP045645:c3710902-3710645 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT142249 NZ_CP060491:2042583-2042843 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5N0FZY3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References