Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5814206..5815951 Replicon chromosome
Accession NZ_CP045644
Organism Variovorax paradoxus strain 5C-2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GFK26_RS26880 Protein ID WP_153284638.1
Coordinates 5815082..5815951 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GFK26_RS26875 Protein ID WP_099796581.1
Coordinates 5814206..5815045 (-) Length 280 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFK26_RS26855 5809348..5810823 - 1476 WP_153284634.1 aldehyde dehydrogenase -
GFK26_RS26860 5810840..5811640 - 801 WP_153284635.1 aspartate dehydrogenase -
GFK26_RS26865 5811661..5813358 - 1698 WP_153284636.1 thiamine pyrophosphate-binding protein -
GFK26_RS26870 5813351..5814190 - 840 WP_153284637.1 SDR family oxidoreductase -
GFK26_RS26875 5814206..5815045 - 840 WP_099796581.1 IclR family transcriptional regulator Antitoxin
GFK26_RS26880 5815082..5815951 - 870 WP_153284638.1 alpha/beta hydrolase Toxin
GFK26_RS26885 5815975..5816472 - 498 WP_194274149.1 cupin domain-containing protein -
GFK26_RS26890 5816568..5817326 - 759 WP_194274150.1 SDR family oxidoreductase -
GFK26_RS26895 5817403..5818386 - 984 WP_153284640.1 tripartite tricarboxylate transporter substrate binding protein -
GFK26_RS26900 5818579..5819838 - 1260 WP_153284641.1 D-amino acid dehydrogenase -
GFK26_RS26905 5819893..5820909 - 1017 WP_153284642.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(47-281)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30078.47 Da        Isoelectric Point: 6.0184

>T142248 WP_153284638.1 NZ_CP045644:c5815951-5815082 [Variovorax paradoxus]
MGTIDIPAQTLPAFELARLDARFPARDVAVGNGAVVSVRECGQGPVIVCLHGIGSGAASWLDTAALLAPQACLIAWDAPG
YGRSTPLASATPTAADYAARLEEMLDALSIRSCVLVGHSLGAITAASAARNESSASARIRRLVLVSPAIGYGAPERIDAR
AKVRAERLATLDDLGIAGMAAKRAGRLVSDGASEHARQWVRWNMARLNDHGYRQAVELLCNADLLADLPPPMPVRVACGA
LDVVTPPAACEEVARRCGVPLELVDDAGHAGYVEQPQAVAALLRESLAG

Download         Length: 870 bp

>T142248 NZ_CP060491:c1042905-1042810 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 280 a.a.        Molecular weight: 30776.17 Da        Isoelectric Point: 5.7705

>AT142248 WP_099796581.1 NZ_CP045644:c5815045-5814206 [Variovorax paradoxus]
MATDNEVMEEGADRYNVPALERGLRVLCEFSRESRTLSAPELARRFDLPRSTVFRLLTTLENMGFLERAEGGRDYRLGLA
VLRLGFEYLASLELTQLGTPLLNRLCDELRTPCNLVVRDGRSIVYVAKVAPATPFASSVTVGTRLPAHATVLGRILLEDL
TLPQLRALYPEDKLETFSPSTPKTVNELFDMVQADRQRGYVLGEGFFESNISTIAAPVRDHSGHIVAALGATITSGHIDE
NRMDEMVLRVRGTADEISGLLNYSPARNSTAKVVPLRSA

Download         Length: 840 bp

>AT142248 NZ_CP060491:1042723-1042782 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References