Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2959239..2959844 Replicon chromosome
Accession NZ_CP045644
Organism Variovorax paradoxus strain 5C-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GFK26_RS13550 Protein ID WP_153282403.1
Coordinates 2959656..2959844 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GFK26_RS13545 Protein ID WP_101493227.1
Coordinates 2959239..2959655 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFK26_RS13530 2956247..2957599 + 1353 WP_153282400.1 hypothetical protein -
GFK26_RS13535 2957629..2958603 + 975 WP_153282401.1 tripartite tricarboxylate transporter substrate binding protein BugD -
GFK26_RS13540 2958676..2959116 + 441 WP_153282402.1 hypothetical protein -
GFK26_RS13545 2959239..2959655 - 417 WP_101493227.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GFK26_RS13550 2959656..2959844 - 189 WP_153282403.1 type II toxin-antitoxin system HicA family toxin Toxin
GFK26_RS13555 2959998..2960876 - 879 WP_153282404.1 hypothetical protein -
GFK26_RS13560 2961099..2962256 - 1158 WP_153282405.1 alpha-hydroxy-acid oxidizing protein -
GFK26_RS13565 2962393..2963286 - 894 WP_153282406.1 LysR family transcriptional regulator -
GFK26_RS13570 2963320..2963901 - 582 WP_153282407.1 TetR/AcrR family transcriptional regulator -
GFK26_RS13575 2963989..2964411 + 423 WP_153282408.1 nuclear transport factor 2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6944.18 Da        Isoelectric Point: 11.0388

>T142247 WP_153282403.1 NZ_CP045644:c2959844-2959656 [Variovorax paradoxus]
MKTSEFKRYLASLGATFLEGKKHTKVYLNGKQTTLPRHATEELGLGLRMLILRQSGVNPKGK

Download         Length: 189 bp

>T142247 NZ_CP060491:984052-984204 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15098.53 Da        Isoelectric Point: 8.5745

>AT142247 WP_101493227.1 NZ_CP045644:c2959655-2959239 [Variovorax paradoxus]
MFSYPARIARDGDGFVVSFPDIPEALTGAKSRTKALELALDALTTAMDFYFEDRRPVPLPSSLKRGQVAIDLPASVSAKV
LLLNEMIAQGARPAELARRMDARPQEVTRLLDLHHPTKIDTVAAALQALGKRLEFSLV

Download         Length: 417 bp

>AT142247 NZ_CP060491:983428-984027 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References