Detailed information of TA system TA142245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4606909..4607422
• Replicon: chromosome
• Accession: NZ_CP045641
• Organism: Klebsiella quasipneumoniae strain KP18-31

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GFK78_RS22040
• Protein ID: WP_130972177.1
• Coordinates: 4606909..4607190 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: GFK78_RS22045
• Protein ID: WP_002886901.1
• Coordinates: 4607180..4607422 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GFK78_RS22025	4601951..4603606	+	1656	WP_049092407.1	alpha,alpha-phosphotrehalase	-
GFK78_RS22030	4603992..4606130	+	2139	WP_135716052.1	anaerobic ribonucleoside-triphosphate reductase	-
GFK78_RS22035	4606441..4606905	+	465	WP_032456904.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
GFK78_RS22040	4606909..4607190	-	282	WP_130972177.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GFK78_RS22045	4607180..4607422	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GFK78_RS22050	4607500..4609410	-	1911	WP_049092409.1	BglG family transcription antiterminator	-
GFK78_RS22055	4609433..4610584	-	1152	WP_017900573.1	lactonase family protein	-
GFK78_RS22060	4610652..4611392	-	741	WP_135716053.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (17-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10964.78 Da
• Isoelectric Point: 10.2278

>T142245 WP_130972177.1 NZ_CP045641:c4607190-4606909 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCDKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQAIKRL

Nucleotide

• Length: 282 bp

>T142245 NZ_CP060491:809983-810345 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT142245 WP_002886901.1 NZ_CP045641:c4607422-4607180 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT142245 NZ_CP060491:809816-809986 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0