Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3884382..3885001 Replicon chromosome
Accession NZ_CP045641
Organism Klebsiella quasipneumoniae strain KP18-31

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GFK78_RS18700 Protein ID WP_002892050.1
Coordinates 3884783..3885001 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GFK78_RS18695 Protein ID WP_002892066.1
Coordinates 3884382..3884756 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFK78_RS18685 3879535..3880728 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GFK78_RS18690 3880751..3883897 + 3147 WP_017898892.1 multidrug efflux RND transporter permease subunit -
GFK78_RS18695 3884382..3884756 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GFK78_RS18700 3884783..3885001 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GFK78_RS18705 3885159..3885725 + 567 WP_004204750.1 maltose O-acetyltransferase -
GFK78_RS24940 3885697..3885819 - 123 WP_032426076.1 hypothetical protein -
GFK78_RS18710 3885862..3886332 + 471 WP_049093338.1 YlaC family protein -
GFK78_RS18715 3886301..3887758 - 1458 WP_153245282.1 PLP-dependent aminotransferase family protein -
GFK78_RS18720 3887859..3888557 + 699 WP_064187826.1 GNAT family N-acetyltransferase -
GFK78_RS18725 3888554..3888694 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GFK78_RS18730 3888694..3888957 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T142244 WP_002892050.1 NZ_CP045641:3884783-3885001 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T142244 NZ_CP060491:788542-788751 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT142244 WP_002892066.1 NZ_CP045641:3884382-3884756 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT142244 NZ_CP060491:788237-788530 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References