Detailed information of TA system TA142242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2564018..2565606
• Replicon: chromosome
• Accession: NZ_CP045641
• Organism: Klebsiella quasipneumoniae strain KP18-31

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GFK78_RS12400
• Protein ID: WP_004205919.1
• Coordinates: 2564018..2565340 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2A5MFC9
• Locus tag: GFK78_RS12405
• Protein ID: WP_004205921.1
• Coordinates: 2565340..2565606 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GFK78_RS12365	2559100..2559318	+	219	WP_002904808.1	ParD-like family protein	-
GFK78_RS12370	2559299..2560081	+	783	WP_153245181.1	type I methionyl aminopeptidase	-
GFK78_RS12375	2560350..2561465	+	1116	WP_049093366.1	serine hydrolase	-
GFK78_RS12380	2561452..2561796	+	345	WP_004205915.1	hypothetical protein	-
GFK78_RS12385	2561825..2562358	+	534	WP_004205916.1	hypothetical protein	-
GFK78_RS12390	2562361..2562567	+	207	WP_004205917.1	helix-turn-helix transcriptional regulator	-
GFK78_RS12395	2562709..2564001	+	1293	WP_017900382.1	glycoside hydrolase family 10 protein	-
GFK78_RS12400	2564018..2565340	-	1323	WP_004205919.1	type II toxin-antitoxin system HipA family toxin	Toxin
GFK78_RS12405	2565340..2565606	-	267	WP_004205921.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
GFK78_RS12410	2565889..2566215	-	327	WP_064187240.1	hydroxyisourate hydrolase	-
GFK78_RS12415	2566212..2566712	-	501	WP_004205925.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
GFK78_RS12420	2566690..2568069	-	1380	WP_017900377.1	purine permease	-
GFK78_RS12425	2568415..2569569	+	1155	WP_004205928.1	FAD-dependent urate hydroxylase HpxO	-
GFK78_RS12430	2569550..2570473	-	924	WP_004205929.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49013.27 Da
• Isoelectric Point: 8.2655

>T142242 WP_004205919.1 NZ_CP045641:c2565340-2564018 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Nucleotide

• Length: 1323 bp

>T142242 NZ_CP060491:466111-466377 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9940.38 Da
• Isoelectric Point: 7.1997

>AT142242 WP_004205921.1 NZ_CP045641:c2565606-2565340 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT142242 NZ_CP060491:465860-466111 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A2A5MFC9