Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 816192..816849 Replicon chromosome
Accession NZ_CP045641
Organism Klebsiella quasipneumoniae strain KP18-31

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag GFK78_RS04015 Protein ID WP_004205323.1
Coordinates 816439..816849 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GFK78_RS04010 Protein ID WP_002916312.1
Coordinates 816192..816458 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFK78_RS03985 811400..812833 - 1434 WP_135715962.1 6-phospho-beta-glucosidase BglA -
GFK78_RS03990 812952..813680 - 729 WP_094333724.1 MurR/RpiR family transcriptional regulator -
GFK78_RS03995 813731..814042 + 312 WP_094333725.1 N(4)-acetylcytidine aminohydrolase -
GFK78_RS04000 814205..814864 + 660 WP_004205319.1 hemolysin III family protein -
GFK78_RS04005 814963..815946 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
GFK78_RS04010 816192..816458 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GFK78_RS04015 816439..816849 + 411 WP_004205323.1 protein YgfX Toxin
GFK78_RS04020 816856..817377 - 522 WP_004205324.1 flavodoxin FldB -
GFK78_RS04025 817478..818374 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GFK78_RS04030 818397..819110 + 714 WP_135715961.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GFK78_RS04035 819116..820849 + 1734 WP_094333727.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T142233 WP_004205323.1 NZ_CP045641:816439-816849 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T142233 NZ_CP060470:2479674-2480087 [Xanthomonas citri pv. citri]
ATGGCCGCGGGTAAGGGCAAAGTGTTTCTCGACAGCAACGTGGTGCTCTACCTGCTGTCGGAGGATGCGGTGAAGGCGGA
CGGCGCGGAGGCATTGCTGCAGCGCAGGCCCGTCATCAGTGTGCAGGTGCTCAATGAAGTGACCCACGTCTGCGTTCGCA
AGCTCAAGATGGGCTGGGACGAAGTCGGGCAGTTCCTTGCGTTGGTGCGATCGTTCTGCAAGATAGTGCCTCTGACGGTC
GATGTTCACGACCGTGCGCGCCAGCTGGCGGAGCGGCACCAATTGTCGTTCTACGACGCGTGCATCGTGGCGGCGGCCGC
CATCGAAGGGTGCCAGACCCTCTACTCCGAAGACATGCACCACGGCCTCATCATCGAAGAGAGCCTGTCGATTCGGAACC
CGTTCAACGTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT142233 WP_002916312.1 NZ_CP045641:816192-816458 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142233 NZ_CP060470:2479454-2479687 [Xanthomonas citri pv. citri]
ATGCAAGTCGCGAAGTGGGGTAACAGCCTGGCGGTGCGCCTGCCGTCCAGTCTGGTGGAAGCGCTGGAACTGCGCGAGGG
CGACGACATCGAGATCGTCGTCGATGATCCGCGATTGTTCGCGGTGCGCAAGAAGCCGGGTCCGGAGGCCATGTTGGAGC
GGCTGCGTGCCTTCCGGGGCAAGTTGCCCGCAGATTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References