Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3143866..3144486 Replicon chromosome
Accession NZ_CP045640
Organism Yersinia pestis strain S19960127

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag S96127_RS15270 Protein ID WP_002208622.1
Coordinates 3144283..3144486 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag S96127_RS15265 Protein ID WP_002218472.1
Coordinates 3143866..3144234 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S96127_RS15250 3142061..3142321 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
S96127_RS15255 3142337..3142480 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
S96127_RS15260 3143354..3143707 + 354 WP_002208619.1 hypothetical protein -
S96127_RS15265 3143866..3144234 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
S96127_RS15270 3144283..3144486 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
S96127_RS15280 3145374..3145763 + 390 WP_002208623.1 MGMT family protein -
S96127_RS15285 3145899..3146420 - 522 WP_002208624.1 lipoprotein -
S96127_RS15290 3146677..3147537 + 861 WP_002208625.1 acyl-CoA thioesterase II -
S96127_RS15295 3147797..3149086 - 1290 WP_002228344.1 ammonium transporter AmtB -
S96127_RS15300 3149126..3149464 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-64)

Antitoxin

(1-118)


Sequences


Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T142231 WP_002208622.1 NZ_CP045640:3144283-3144486 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T142231 NZ_CP060470:99921-100220 [Xanthomonas citri pv. citri]
ATGGCTGAAATAATCTGGTCGGTGCCGGCATTGGCTGATCTGGACGCAATTGCCGACTACATCGCAATCGATAACGCACC
CGCTGCAGCGGCGCTGGTGAAACGGGTGTTCGGGCACGTTGAGCAATTGATCGAACACCCGGACAGCGGAAGCCGACCAC
AGGAACTCAAGCGCTCGCGCTATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGCATC
GTGGTGGTGCACGTCATGCGGTCGGAGCGCGCGCTTCGCGGGAACCGTCTTTCACGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT142231 WP_002218472.1 NZ_CP045640:3143866-3144234 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT142231 NZ_CP060470:99676-99933 [Xanthomonas citri pv. citri]
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACTCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGTGCCTATCTGGTGGATGTTGCCAGCTATGAGCGCATGCAGCAGCGCATTGCGC
TCCTCGAAGGAATCGCCCGTGGAGAAATGGCAGTCGCGGAAGGCCGTACGCTGAGCCATGAACAGGCACGGCACCGCATG
GCGCGATGGCTGAAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 2K5S


Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References