Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2216963..2217929 Replicon chromosome
Accession NZ_CP045640
Organism Yersinia pestis strain S19960127

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag S96127_RS11120 Protein ID WP_002210981.1
Coordinates 2217471..2217929 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag S96127_RS11115 Protein ID WP_002210982.1
Coordinates 2216963..2217409 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S96127_RS11095 2212552..2213526 - 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
S96127_RS11100 2213689..2214192 + 504 WP_002210984.1 thiol peroxidase -
S96127_RS11105 2214445..2214903 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
S96127_RS11110 2215050..2216627 - 1578 WP_002210983.1 transcriptional regulator TyrR -
S96127_RS11115 2216963..2217409 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
S96127_RS11120 2217471..2217929 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
S96127_RS11125 2217939..2219000 - 1062 WP_002210980.1 YcjF family protein -
S96127_RS11130 2218997..2220394 - 1398 WP_002210979.1 YcjX family protein -
S96127_RS11135 2220375..2220617 - 243 WP_002216375.1 phage shock protein PspD -
S96127_RS11140 2220702..2221061 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
S96127_RS11145 2221061..2221288 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
S96127_RS11150 2221450..2222115 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2214445..2214903 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T142230 WP_002210981.1 NZ_CP045640:2217471-2217929 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T142230 NZ_CP060468:c22193-21912 [Xanthomonas citri pv. citri]
ATGCGGACGATTGACCGTTCATCCGCTTTCAAGCGCGACTACAAGCGGGAAGCCAAGGGGCAGCATCGCGCCACGCTTGA
TGACGCGATCAAGCCGGTGTTGGTCGCACTGGCGACCGATCAGCCTCCCGATGCACGCTATCGCGATCACGATCTTTCCG
GCGATTGGGCGGGCTATCGCGAATGTCACATCAAGCCCGACTTGCTGCTGATCTACCGCAAGTCCGACCCCGAAACCCTG
CGACTGGCACGGCTTGGCTCGCACAGCGAGCTTTTCGGCTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT142230 WP_002210982.1 NZ_CP045640:2216963-2217409 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT142230 NZ_CP060468:c22449-22180 [Xanthomonas citri pv. citri]
ATGAGCACTACCGCCGATACCTACGTCCGCGCCCGCATCGACACCGCCACCAAGGAACGTGCCGCTAGTGCGCTCGAAGC
AATGGGGCTGTCGATCTCTGATGCTATCCGCCTGCTGATGCTACGCATTGCCGACGAACACCGCCTGCCCTTCGATGTGA
AGGTACCAAACACCACCACGAAAAAGGCGATTGCCGAACTGGAATCAGGCAAGGGTAAGAAGTTCGCCAATGTGGACGAC
CTGATGGCGGATTTGCATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References