Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1566514..1567160 Replicon chromosome
Accession NZ_CP045640
Organism Yersinia pestis strain S19960127

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag S96127_RS08085 Protein ID WP_002214976.1
Coordinates 1566978..1567160 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag S96127_RS08080 Protein ID WP_002211129.1
Coordinates 1566514..1566933 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S96127_RS08060 1561585..1562580 + 996 WP_002211125.1 substrate-binding domain-containing protein -
S96127_RS08065 1562646..1564223 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
S96127_RS08070 1564226..1565248 + 1023 WP_002214974.1 ABC transporter permease -
S96127_RS08075 1565297..1566256 + 960 WP_002223882.1 sugar kinase -
S96127_RS08080 1566514..1566933 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
S96127_RS08085 1566978..1567160 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
S96127_RS08090 1567367..1568149 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
S96127_RS08095 1568152..1568421 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
S96127_RS08100 1568527..1569267 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
S96127_RS08105 1569348..1569884 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
S96127_RS08110 1569884..1570300 - 417 WP_002211134.1 flagellar motor switch protein FliN -
S96127_RS08115 1570297..1571298 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
S96127_RS08120 1571304..1571774 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T142229 WP_002214976.1 NZ_CP045640:c1567160-1566978 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T142229 NZ_CP060468:12780-13106 [Xanthomonas citri pv. citri]
ATGATGCGAGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCACGGCCCGCTCTGGTCATCCAGGCCAA
CCAGTTTGACGAACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTTGTTGCTGCGCCGCTGCTGCGCATTACCG
TTCATCCAAGTACCGACAATGGCCTGCTGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
ATAGGTCGGGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGAAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT142229 WP_002211129.1 NZ_CP045640:c1566933-1566514 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT142229 NZ_CP060468:12566-12793 [Xanthomonas citri pv. citri]
ATGGCACACGTCAATTCACGAGTTCAAAAGCACCGTGACGCCCTGCGCATGGCAGGGCTGCGTCCGGTGCAAATTTGGGT
GCCGGACACACGGCGGCCTGACTTCGCCGAGGAATGCCGCCGTCAGTGTCGTCTTGCTGCACAAGCGGACATGGAGGACA
CCGACATGCAGCGCTTCATGGATGAGGCGCTAGCAGACATGGATGGCTGGACGGATGATGCGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References