Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 18904..19496 Replicon plasmid unnamed3
Accession NZ_CP045634
Organism Roseibium aggregatum strain ZYF612

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GFK91_RS30250 Protein ID WP_229006519.1
Coordinates 18904..19200 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GFK91_RS30255 Protein ID WP_229006520.1
Coordinates 19206..19496 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFK91_RS30230 (GFK91_30070) 14002..14370 - 369 WP_229006515.1 thermonuclease family protein -
GFK91_RS30235 (GFK91_30075) 15017..15439 - 423 WP_229006516.1 helix-turn-helix transcriptional regulator -
GFK91_RS30240 (GFK91_30080) 16359..16697 + 339 WP_229006517.1 hypothetical protein -
GFK91_RS30245 (GFK91_30085) 16827..18383 - 1557 WP_229006518.1 ISL3 family transposase -
GFK91_RS30250 (GFK91_30090) 18904..19200 + 297 WP_229006519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GFK91_RS30255 (GFK91_30095) 19206..19496 + 291 WP_229006520.1 putative addiction module antidote protein Antitoxin
GFK91_RS30260 (GFK91_30100) 19783..21660 - 1878 WP_229006521.1 adenylate/guanylate cyclase domain-containing protein -
GFK91_RS30265 (GFK91_30105) 21946..22830 - 885 WP_229006522.1 LysR family transcriptional regulator -
GFK91_RS30270 (GFK91_30110) 23115..23483 + 369 WP_229006523.1 c-type cytochrome -
GFK91_RS30275 (GFK91_30115) 23523..23975 + 453 WP_229006524.1 (2Fe-2S)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..186846 186846


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(4-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11020.93 Da        Isoelectric Point: 11.0396

>T142215 WP_229006519.1 NZ_CP045634:18904-19200 [Roseibium aggregatum]
MIEIIKTDIFDRWLVGLRDRQARARIATRIRRLSLGNPGDVKPVGSGISEMRIDHGPGYRVYFMKRGPIVIVLLCAGDKS
SQSRDIALAKTIAAQWKE

Download         Length: 297 bp

>T142215 NZ_CP060460:322052-322186 [Xanthomonas citri pv. citri]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10247.71 Da        Isoelectric Point: 4.7824

>AT142215 WP_229006520.1 NZ_CP045634:19206-19496 [Roseibium aggregatum]
MEVKFSRYDTADYLKTEEDIAGYLDAVMEDGDPALIAAALGDVARARNLSQLAREVGMSRQGLDKALSGEGNPTLATVAK
VAQALGMRLSIKPIVH

Download         Length: 291 bp

>AT142215 NZ_CP060460:321825-321977 [Xanthomonas citri pv. citri]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References