Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 223797..225350 Replicon plasmid unnamed2
Accession NZ_CP045633
Organism Roseibium aggregatum strain ZYF612

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GFK91_RS30010 Protein ID WP_229006327.1
Coordinates 223797..225098 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GFK91_RS30015 Protein ID WP_229006328.1
Coordinates 225099..225350 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFK91_RS29995 (GFK91_29840) 220058..220918 - 861 WP_206911283.1 Abi family protein -
GFK91_RS30000 (GFK91_29845) 221609..222469 - 861 WP_267480531.1 lipase family protein -
GFK91_RS30005 (GFK91_29850) 222795..223190 - 396 WP_022998196.1 hypothetical protein -
GFK91_RS30010 (GFK91_29855) 223797..225098 - 1302 WP_229006327.1 type II toxin-antitoxin system HipA family toxin Toxin
GFK91_RS30015 (GFK91_29860) 225099..225350 - 252 WP_229006328.1 helix-turn-helix transcriptional regulator Antitoxin
GFK91_RS30020 (GFK91_29870) 225859..226296 - 438 WP_229006329.1 MarR family transcriptional regulator -
GFK91_RS30025 (GFK91_29875) 226368..227285 + 918 WP_229006330.1 haloalkane dehalogenase -
GFK91_RS30030 (GFK91_29880) 227409..228590 - 1182 WP_229006331.1 alpha/beta fold hydrolase -
GFK91_RS30035 (GFK91_29885) 228706..229434 - 729 WP_229006332.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..254527 254527


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-66)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48613.47 Da        Isoelectric Point: 6.9154

>T142214 WP_229006327.1 NZ_CP045633:c225098-223797 [Roseibium aggregatum]
MGRRRSYHPLSVFMNTRYVGTLTRESTGAISFAYDKSWLDWENAMPVSLSLPLRKDRYIGAPVMAVFDNLLPDNDDIRKR
VAERVGAQGTDAYSMLSELGRDCIGALQFLPDGEEPHATGKLSGEIVSEDQIEEVLNNLDVAPLGIRKERDFRISVAGAQ
EKTALLYHEGQWIEPSGTTPTTHIIKPQIGKLPNGMDLADSVENEYLCLKLLGAFGLRTANAEMARFGKRKALVVERFDR
LWAKDGRLIRLPQEDFCQVFSIPPTRKYQNEGGPGIVDIIDRLRGSDEPTQDRRDFFKANILFWLMGATDGHAKNFSIAL
MPGGRFRMTPLYDVLTVQPTYDQGQIQRKDFKLAMRFGKSNHYKIENIYGRHIVETGVQGGLSKDAIGNLFEELHQDAPK
AIEKTIKELPNGFPAALIESVQGAISDRLKRLD

Download         Length: 1302 bp

>T142214 NZ_CP060460:321825-321977 [Xanthomonas citri pv. citri]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9310.70 Da        Isoelectric Point: 8.7690

>AT142214 WP_229006328.1 NZ_CP045633:c225350-225099 [Roseibium aggregatum]
MKQLARTPKDIGHAIREARKERRLSQTELASRSGLWQETISKIENGVASTKLETLFDLLAALDLEILVQSRSKGVPSSME
DLF

Download         Length: 252 bp

>AT142214 NZ_CP060460:322052-322186 [Xanthomonas citri pv. citri]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References