Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 3711770..3712362 | Replicon | chromosome |
| Accession | NZ_CP045627 | ||
| Organism | Roseibium aggregatum strain ZYF703 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0NQB4 |
| Locus tag | GFK88_RS17110 | Protein ID | WP_006933117.1 |
| Coordinates | 3711770..3711952 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | GFK88_RS17115 | Protein ID | WP_022998843.1 |
| Coordinates | 3711970..3712362 (+) | Length | 131 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GFK88_RS17085 (GFK88_17020) | 3707009..3708799 | + | 1791 | WP_228868298.1 | DUF262 domain-containing protein | - |
| GFK88_RS17090 (GFK88_17025) | 3708903..3709625 | - | 723 | WP_228868300.1 | hypothetical protein | - |
| GFK88_RS17095 (GFK88_17030) | 3709961..3710203 | + | 243 | WP_228868304.1 | hypothetical protein | - |
| GFK88_RS17100 (GFK88_17035) | 3710390..3710926 | + | 537 | WP_228868305.1 | dihydrofolate reductase family protein | - |
| GFK88_RS17105 (GFK88_17040) | 3710923..3711489 | + | 567 | WP_206906425.1 | TetR/AcrR family transcriptional regulator | - |
| GFK88_RS17110 (GFK88_17045) | 3711770..3711952 | + | 183 | WP_006933117.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| GFK88_RS17115 (GFK88_17050) | 3711970..3712362 | + | 393 | WP_022998843.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| GFK88_RS17120 (GFK88_17055) | 3712525..3712854 | - | 330 | WP_228868308.1 | hypothetical protein | - |
| GFK88_RS17125 | 3712890..3713039 | + | 150 | WP_228868310.1 | hypothetical protein | - |
| GFK88_RS17130 (GFK88_17065) | 3713089..3713439 | - | 351 | WP_228868312.1 | hypothetical protein | - |
| GFK88_RS17135 (GFK88_17070) | 3713439..3713657 | - | 219 | WP_228868314.1 | hypothetical protein | - |
| GFK88_RS17140 (GFK88_17075) | 3713670..3714395 | - | 726 | WP_228868316.1 | M15 family metallopeptidase | - |
| GFK88_RS17145 (GFK88_17080) | 3714475..3715491 | - | 1017 | WP_228868318.1 | late control D family protein | - |
| GFK88_RS17150 (GFK88_17085) | 3715658..3716299 | + | 642 | WP_228868320.1 | hypothetical protein | - |
| GFK88_RS17155 (GFK88_17090) | 3716296..3716511 | - | 216 | WP_228868322.1 | tail protein X | - |
| GFK88_RS17160 (GFK88_17095) | 3716514..3716951 | - | 438 | WP_228868324.1 | phage tail protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3711770..3764354 | 52584 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6772.96 Da Isoelectric Point: 10.6579
>T142209 WP_006933117.1 NZ_CP045627:3711770-3711952 [Roseibium aggregatum]
METNSRKIIKKLEEDGFELVKVVGSHHKFKKGSLTVTVPHPKKDLPVGTVRSIYKQAGWV
METNSRKIIKKLEEDGFELVKVVGSHHKFKKGSLTVTVPHPKKDLPVGTVRSIYKQAGWV
Download Length: 183 bp
>T142209 NZ_CP060453:5110546-5110962 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA
Antitoxin
Download Length: 131 a.a. Molecular weight: 13784.51 Da Isoelectric Point: 4.4368
>AT142209 WP_022998843.1 NZ_CP045627:3711970-3712362 [Roseibium aggregatum]
MHNYVALVHQDGDSAYGVQFPDVPGCFSAADEIDQLVRNATEALALHLEGETLPSPRSLAEIRNDEDVASALAEGAFLIA
VPLISLSGRTVKANITMDAGLLDAVDHTAKARGLTRSAYLADLARRDIAV
MHNYVALVHQDGDSAYGVQFPDVPGCFSAADEIDQLVRNATEALALHLEGETLPSPRSLAEIRNDEDVASALAEGAFLIA
VPLISLSGRTVKANITMDAGLLDAVDHTAKARGLTRSAYLADLARRDIAV
Download Length: 393 bp
>AT142209 NZ_CP060453:5110295-5110549 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|