Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4796303..4796923 Replicon chromosome
Accession NZ_CP045611
Organism Enterobacter hormaechei strain AUH-ENM30

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag GBT00_RS22970 Protein ID WP_015571250.1
Coordinates 4796705..4796923 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GBT00_RS22965 Protein ID WP_006809850.1
Coordinates 4796303..4796677 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBT00_RS22955 4791430..4792623 + 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GBT00_RS22960 4792646..4795792 + 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
GBT00_RS22965 4796303..4796677 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GBT00_RS22970 4796705..4796923 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
GBT00_RS22975 4797132..4797683 + 552 WP_022650496.1 maltose O-acetyltransferase -
GBT00_RS22980 4797800..4798267 + 468 WP_022650495.1 hypothetical protein -
GBT00_RS22985 4798239..4799699 - 1461 WP_022650494.1 PLP-dependent aminotransferase family protein -
GBT00_RS22990 4799801..4800511 + 711 WP_022650493.1 GNAT family N-acetyltransferase -
GBT00_RS22995 4800508..4800648 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GBT00_RS23000 4800651..4800911 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T142201 WP_015571250.1 NZ_CP045611:4796705-4796923 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T142201 NZ_CP060448:c7569-7237 [Xanthomonas citri pv. citri]
ATGGATCGCGGCGATGTCTATTTGGTTTCGCTCGATCCCACGTCCGGCCATGAACAACAGGGCACGCGCCCGGTGCTGAT
TGTGTCGCCAAGCGCGTTCAACCGCCTGACGAAAACACCGGTCGTGCTGCCGATCACCAGTGGGGGTAACTTCGCCCGCA
CGGCAGGCTTTACCGTGTCGCTCATGGGTGCGGGTACCAACACAACTGGCGTAGTTCGCTGCGATCAGCCCCGCGCTCTC
GATCTAGCCTCGCGGCGCGCGCGCAAGCTGGAAACCGTGCCGTCCCCGATCATGGATGAGGTATTAGCGAAGCTGAGCGC
GATCCTTGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT142201 WP_006809850.1 NZ_CP045611:4796303-4796677 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT142201 NZ_CP060448:c7826-7569 [Xanthomonas citri pv. citri]
ATGCATACGACCAATCTGCGTAAGGTCGGTGGCTCGATCATGTTGGCTGTCCCGCCCGCCATTCTGGATATGCTGCGTCT
GCGTGCCGGCGCTACCGTTGGCTTGGCCGTCGATCATGGTCGCCTGGTGATCGAACCCACGCTGCGTCCGTACTACAGCC
TGGATGAGCTGCTGGCCCAATGCGACGCATCCGCCGAACTCTCCACCGAAGATCGGGAATGGCTCGACGCCAAGCCTGTT
GGCAGCGAGCTGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References