Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3581717..3582456 Replicon chromosome
Accession NZ_CP045611
Organism Enterobacter hormaechei strain AUH-ENM30

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag GBT00_RS17090 Protein ID WP_003857133.1
Coordinates 3581971..3582456 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag GBT00_RS17085 Protein ID WP_003857131.1
Coordinates 3581717..3581983 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBT00_RS17065 3577193..3578179 + 987 WP_022651202.1 DUF979 domain-containing protein -
GBT00_RS17070 3578189..3579184 + 996 WP_003857125.1 DUF2891 domain-containing protein -
GBT00_RS17075 3579206..3580594 - 1389 WP_032645625.1 MFS transporter -
GBT00_RS17080 3580724..3581653 + 930 WP_022651200.1 LysR family transcriptional regulator -
GBT00_RS17085 3581717..3581983 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
GBT00_RS17090 3581971..3582456 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
GBT00_RS17095 3582831..3583310 + 480 WP_001542736.1 hypothetical protein -
GBT00_RS17100 3583332..3584135 + 804 WP_039268887.1 TIGR02391 family protein -
GBT00_RS17105 3584156..3585589 + 1434 WP_004016055.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T142199 WP_003857133.1 NZ_CP045611:3581971-3582456 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T142199 NZ_CP060446:c4711883-4711731 [Xanthomonas citri pv. citri]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT142199 WP_003857131.1 NZ_CP045611:3581717-3581983 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT142199 NZ_CP060446:c4711656-4711522 [Xanthomonas citri pv. citri]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References