Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1968940..1969597 Replicon chromosome
Accession NZ_CP045611
Organism Enterobacter hormaechei strain AUH-ENM30

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag GBT00_RS09325 Protein ID WP_022649305.1
Coordinates 1969187..1969597 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GBT00_RS09320 Protein ID WP_003863437.1
Coordinates 1968940..1969206 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBT00_RS09300 1964372..1965805 - 1434 WP_108400176.1 6-phospho-beta-glucosidase -
GBT00_RS09305 1965922..1966653 - 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
GBT00_RS09310 1966920..1967579 + 660 WP_003863433.1 hemolysin III family protein -
GBT00_RS09315 1967665..1968645 - 981 WP_003863435.1 tRNA-modifying protein YgfZ -
GBT00_RS09320 1968940..1969206 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GBT00_RS09325 1969187..1969597 + 411 WP_022649305.1 protein YgfX Toxin
GBT00_RS09330 1969599..1970120 - 522 WP_003863440.1 flavodoxin FldB -
GBT00_RS09335 1970222..1971118 + 897 WP_022651809.1 site-specific tyrosine recombinase XerD -
GBT00_RS09340 1971147..1971860 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GBT00_RS09345 1971866..1973599 + 1734 WP_022651808.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T142189 WP_022649305.1 NZ_CP045611:1969187-1969597 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T142189 NZ_CP060441:c3086499-3086197 [Citrobacter cronae]
ATGTCTAAATCATTAAATATCAGAAATTTTCGGGATACATGGCTTGAAGATTTTTTTGAGCGGGCAACACCGCACAGAAA
AATACCCGCGGATATTCACACCGCATTAGCCAGAAAGCTGGATATCATCAATGCGGCGGTTTCGCATCGGGATTTGCGCT
CGCCGCCAGGGAATAGATATGAAGAGTTAACCGGAAAGTTACAGGAATATTCTTCAATAAGAGTAAATAAGCAGTACCGA
TTAATATTTAAATGGGTTAACGGTAAGGCCGAAGATGTGTACTTAGACCCACACATCTACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT142189 WP_003863437.1 NZ_CP045611:1968940-1969206 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT142189 NZ_CP060441:c3086177-3085836 [Citrobacter cronae]
ATGAAACAGGCAACCAGAAAACCAACTACTGTGGGTGATGTCCTGCAATATGAATACCTGGAGCCGCTCGATCTGAAAAT
TAACGATCTAGCTGAAATACTGCATGTTCACCGTAATACGGTGAGCGCACTGGTCAATAATAATCGCAAATTAACAACGG
ATATGGCATTTCGCCTGGCGAAAGCGTTTGATACCTCCGTTGATTTCTGGCGTAACCTACAGTCGGCGGTTGACCTGTGG
GAAGTTGAAAATGACATGCGGGCGCAAGAAGAACTGAACCGTATTATGTCTGTTAAAGACTTTGTCGCGCAGCGAAATGT
CGCCACTAAGAAAGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References