Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 709250..709846 Replicon chromosome
Accession NZ_CP045611
Organism Enterobacter hormaechei strain AUH-ENM30

Toxin (Protein)


Gene name PumA Uniprot ID A0A5D9Q9B8
Locus tag GBT00_RS03350 Protein ID WP_003860348.1
Coordinates 709250..709552 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag GBT00_RS03355 Protein ID WP_022650216.1
Coordinates 709559..709846 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBT00_RS03330 705469..706818 + 1350 WP_003860344.1 lysine-sensitive aspartokinase 3 -
GBT00_RS03335 706912..707856 + 945 WP_022650218.1 ketopantoate/pantoate/pantothenate transporter PanS -
GBT00_RS03340 707907..708179 + 273 WP_003860346.1 DUF3811 domain-containing protein -
GBT00_RS03345 708180..709052 - 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
GBT00_RS03350 709250..709552 + 303 WP_003860348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GBT00_RS03355 709559..709846 + 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
GBT00_RS03360 709843..711474 - 1632 WP_003860350.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11393.20 Da        Isoelectric Point: 10.1042

>T142188 WP_003860348.1 NZ_CP045611:709250-709552 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHLGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T142188 NZ_CP060441:c2922650-2922369 [Citrobacter cronae]
ATGACCTATAGTCTGGAGTTTTTAGATATTGCGCTCAAGGAGTGGCGCAAACTTTCACCCACATTACGCGAGCAGTTCAA
AAAGAAGCTAGCGGAACGGCTAGAGAACCCTCATGTCCCTGCCGCCCGCCTGTCTGGCAAATTACACCGTTATAAAATCA
AGCTACGCAGTGCCGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCCGTGGGCAGA
CGTGATGGCGATGAGGTTTATCATCAGGCTAACCGGCGCTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT142188 WP_022650216.1 NZ_CP045611:709559-709846 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT142188 NZ_CP060441:c2922888-2922640 [Citrobacter cronae]
ATGCCATTTCACATACTGACCAAAACTGCAGCCAGCATCACCGACCTGAAACGTAACCCGATGGGGACGGTTAACGCAGG
GGAAGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCAGCGTTTTACTGCGTGCCGCCTGCGGTCTATGCGTATTTGC
TGGAGCTGGCAGAAGATGCGGAGCTGAACCGTATCGCCGACGAACGTGAAGGTGGAAAGCGAATACAGGTGTCTTTAAAT
GACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D9Q9B8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References