142187

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 425831..426534 Replicon chromosome
Accession NZ_CP045611
Organism Enterobacter hormaechei strain AUH-ENM30

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8B5ZZ18
Locus tag GBT00_RS02000 Protein ID WP_039268718.1
Coordinates 425831..426172 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8B5ZWQ9
Locus tag GBT00_RS02005 Protein ID WP_039268717.1
Coordinates 426193..426534 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBT00_RS01980 422357..422728 + 372 WP_022650323.1 hypothetical protein -
GBT00_RS01985 422786..423253 - 468 WP_022650322.1 SymE family type I addiction module toxin -
GBT00_RS01990 423553..424389 + 837 Protein_383 HNH endonuclease -
GBT00_RS01995 424569..425576 - 1008 WP_039268719.1 restriction endonuclease -
GBT00_RS02000 425831..426172 - 342 WP_039268718.1 TA system toxin CbtA family protein Toxin
GBT00_RS02005 426193..426534 - 342 WP_039268717.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GBT00_RS02010 426545..427087 - 543 WP_045259572.1 DNA repair protein RadC -
GBT00_RS02015 427100..427540 - 441 WP_039268716.1 antirestriction protein -
GBT00_RS02020 427571..428392 - 822 WP_039268715.1 DUF945 domain-containing protein -
GBT00_RS02025 428513..428986 - 474 WP_039268714.1 hypothetical protein -
GBT00_RS02030 429058..429510 - 453 WP_039269148.1 hypothetical protein -
GBT00_RS02035 429546..430262 - 717 WP_039268713.1 WYL domain-containing protein -
GBT00_RS02040 430506..431381 - 876 WP_039268712.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 417886..473089 55203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12772.83 Da        Isoelectric Point: 9.6548

>T142187 WP_039268718.1 NZ_CP045611:c426172-425831 [Enterobacter hormaechei]
MKTLPATTPQAAKLCLLPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T142187 NZ_CP060441:c1612476-1612373 [Citrobacter cronae]
GGCAGGGTAACTTAGCCTGCATTTATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12729.40 Da        Isoelectric Point: 6.9460

>AT142187 WP_039268717.1 NZ_CP045611:c426534-426193 [Enterobacter hormaechei]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRVSITGKFSEAECLKLDVAFPHFISQMESMLTTGGMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT142187 NZ_CP060441:1612364-1612511 [Citrobacter cronae]
TAATCATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAA
AGTTGGCATAAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5ZZ18

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5ZWQ9

References