Detailed information of TA system TA142157

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1005115..1006547
• Replicon: chromosome
• Accession: NZ_CP045596
• Organism: Streptococcus thermophilus strain TK-P3A

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: GFB63_RS05255
• Protein ID: WP_111679138.1
• Coordinates: 1005115..1005960 (-)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: F8LVV9
• Locus tag: GFB63_RS05260
• Protein ID: WP_014621283.1
• Coordinates: 1005957..1006547 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GFB63_RS05250	1002228..1005028	+	2801	Protein_976	CHAP domain-containing protein	-
GFB63_RS05255	1005115..1005960	-	846	WP_111679138.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
GFB63_RS05260	1005957..1006547	-	591	WP_014621283.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32428.07 Da
• Isoelectric Point: 5.0493

>T142157 WP_111679138.1 NZ_CP045596:c1005960-1005115 [Streptococcus thermophilus]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMISLITIIISTDFD

Nucleotide

• Length: 846 bp

>T142157 NZ_CP060421:1969417-1969519 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23313.88 Da
• Isoelectric Point: 7.8482

>AT142157 WP_014621283.1 NZ_CP045596:c1006547-1005957 [Streptococcus thermophilus]
MSKKEILFEFIENHNGIITYKDCKALKIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAIFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp

>AT142157 NZ_CP060421:c1969526-1969381 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Antitoxin

• AlphaFold DB: F8LVV9