Detailed information of TA system TA142149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2900725..2901131
• Replicon: chromosome
• Accession: NZ_CP045571
• Organism: Acidithiobacillus thiooxidans ATCC 19377

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GCD22_RS15260
• Protein ID: WP_010637141.1
• Coordinates: 2900725..2900868 (-)
• Length: 48 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A5P9XVS6
• Locus tag: GCD22_RS15265
• Protein ID: WP_024894798.1
• Coordinates: 2900865..2901131 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCD22_RS15225	2897702..2897920	+	219	WP_024894793.1	hypothetical protein	-
GCD22_RS15230	2898022..2898606	+	585	WP_051690411.1	GNAT family N-acetyltransferase	-
GCD22_RS15235	2898696..2898962	+	267	WP_031568684.1	DUF29 domain-containing protein	-
GCD22_RS15245	2899424..2899753	+	330	WP_024894796.1	YnfA family protein	-
GCD22_RS15250	2899853..2900410	+	558	WP_176212067.1	hypothetical protein	-
GCD22_RS15260	2900725..2900868	-	144	WP_010637141.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
GCD22_RS15265	2900865..2901131	-	267	WP_024894798.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GCD22_RS15270	2901269..2901958	-	690	WP_081577592.1	ABC transporter ATP-binding protein	-
GCD22_RS15275	2901951..2903195	-	1245	WP_031568515.1	lipoprotein-releasing ABC transporter permease subunit	-
GCD22_RS15280	2903198..2904679	-	1482	WP_031568517.1	lysine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (7-46)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-81)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5353.16 Da
• Isoelectric Point: 9.0934

>T142149 WP_010637141.1 NZ_CP045571:c2900868-2900725 [Acidithiobacillus thiooxidans ATCC 19377]
MTGLHHSGDWAGYRECHVKPDLLLIYRKSNTHTLKLARLGSLSELFS

Nucleotide

• Length: 144 bp

>T142149 NZ_CP060414:1705137-1705319 [Neisseria musculi]
ATGAAATACAGTGAATTTAGACGATGGCTTATCTCTCAAGGTGTAGAGTTTACCACGCAAAAACGCGGAAGCCATCAGTT
AATCAGATTAGGTAATAGAACATCGGTTTTTCCAAACCACGGCAGTAAAGAAATCGGCTCAGGCTTGGTAAAGAAAATCA
AAAAAGACTTGAACCTTAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9707.09 Da
• Isoelectric Point: 5.8632

>AT142149 WP_024894798.1 NZ_CP045571:c2901131-2900865 [Acidithiobacillus thiooxidans ATCC 19377]
MSTTDTYVRARIDTNTKERAAEALEAMGLSVSDAIRLLMLRIADERRLPFEVKVPNTTTRKAIAELEAGKGKRFASVDDL
MADLHAGD

Nucleotide

• Length: 267 bp

>AT142149 NZ_CP060414:1705382-1705798 [Neisseria musculi]
ATGTTATCTTATCGCTACGAACTCACCCCGGACGATAACGGAACTTTTTTAGTTACGTTTCCCGATATTCCCGAAGCGGT
GGCCGTGGGTGAAGATAAAGAATCGGCAGCAATCGAAGCATTAGATGGTTTGTTGTGCGCACTCGATGGCTACTTTGAAG
ATCGACGCGCTATTCCGCTACCATCAACGGAACAAGGAAGCGACACCGTTACCTTACCCGCCTTGGAAACTGCAAAAGTA
TTGCTGCTTAACGAAATGATCGCACAAGGTGTAAAAAAAGCAGAAATGGCACGCCGTCTAGATGTCCACATGCCCCAAAT
AGACCGCTTGTTAGATTTGCGTCACAATACCAAAATTGATTTTTTGGAAAAAGCAGCAGAAAAGCTGGGAAAGCATTTAA
GCATCAGCTTTGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A5P9XVS6