Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2586364..2586917 Replicon chromosome
Accession NZ_CP045571
Organism Acidithiobacillus thiooxidans ATCC 19377

Toxin (Protein)


Gene name parE Uniprot ID A0A5P9XSP3
Locus tag GCD22_RS13660 Protein ID WP_010642161.1
Coordinates 2586603..2586917 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5P9XTS7
Locus tag GCD22_RS13655 Protein ID WP_031574175.1
Coordinates 2586364..2586603 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCD22_RS13630 2582924..2583139 - 216 WP_080707851.1 DUF2442 domain-containing protein -
GCD22_RS13635 2583238..2583573 - 336 WP_211371670.1 hypothetical protein -
GCD22_RS13640 2583807..2585069 + 1263 WP_153940366.1 IS256 family transposase -
GCD22_RS13645 2585112..2585834 - 723 WP_176211946.1 hypothetical protein -
GCD22_RS13650 2585893..2586312 + 420 WP_031574172.1 phage integrase N-terminal SAM-like domain-containing protein -
GCD22_RS13655 2586364..2586603 + 240 WP_031574175.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GCD22_RS13660 2586603..2586917 + 315 WP_010642161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GCD22_RS13665 2586914..2588221 - 1308 WP_081576945.1 two-component sensor histidine kinase -
GCD22_RS13670 2588218..2588880 - 663 WP_081576944.1 response regulator transcription factor -
GCD22_RS13675 2588960..2589271 - 312 WP_010642165.1 PepSY domain-containing protein -
GCD22_RS13680 2589363..2589944 - 582 WP_010642168.1 cytochrome b/b6 domain-containing protein -
GCD22_RS13685 2590049..2591125 - 1077 WP_153940838.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2583807..2585069 1262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12303.11 Da        Isoelectric Point: 8.5097

>T142148 WP_010642161.1 NZ_CP045571:2586603-2586917 [Acidithiobacillus thiooxidans ATCC 19377]
MGVFALTLAAKNDLRGIARFTEERWGRAQRLHYLKGLDETFKILADSPRLGNPCDYIEPDLRKHPFQSHVVFYNCRSEEE
IQVIRVLHKNMDTQYRMLLRHSET

Download         Length: 315 bp

>T142148 NZ_CP060414:1684713-1684889 [Neisseria musculi]
ATGAAGCAAAGCGAGTTCCTAAAGTGGCTGATTGCACAAGGGGTTGAAACCAGAGAGGGTACGAAACACATCAAACTTTT
CTACAACGGCAAACAATCCCACCTGCCCCGCCACCCGGGCAAGGAATTAAAAACAGGTTTGGTGCAGGGCATCAAAAAAC
AGTTAGGCTTAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8682.66 Da        Isoelectric Point: 4.7344

>AT142148 WP_031574175.1 NZ_CP045571:2586364-2586603 [Acidithiobacillus thiooxidans ATCC 19377]
MSKNTSVSLGNHFDQFIAAQLSRGRYGSATEVVRAGLRLLENEEQKLEALRQLIAEGRASGTAAYSYETFMAELDNELG

Download         Length: 240 bp

>AT142148 NZ_CP060414:1684923-1685345 [Neisseria musculi]
ATGTTTTATCCCGCCGCGTTCACACCCGCCGAAGAGGGCGGTTATGTGGTTACTTTCCCCGACATACCCGAAGCCATCAC
ACAGGGCGACGATTTAACCGAAGCCCGCGAAATGGCGGCAGATGTGCTGCTTTCGGCAATGGATTTCTATTTTGAAGACC
GCCGCCCGGTGCCGCTGCCTTCCAAACCGAAAAAAGGCGAAGAGTGGGTTGCCCTGCCTGCAAGCGTGTTTGCCAAAGTG
CTGCTGCTCAACGAAATGCTGGCGCAAAACATCAGCAATGCCGAACTGGCGCGGCGCATGGAAATCCGCCCGCAGGAAGT
GCAGCGCATCACCAACCTCAACCACACAACCAAAATCGACACCATCGCCCGCGCCCTGATGCAGTTGGGCAAACACTTGA
CCGTCAATACGGTTTCAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P9XSP3

Antitoxin

Source ID Structure
AlphaFold DB A0A5P9XTS7

References