Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 2091960..2092639 | Replicon | chromosome |
| Accession | NZ_CP045571 | ||
| Organism | Acidithiobacillus thiooxidans ATCC 19377 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | GCD22_RS11080 | Protein ID | WP_031575116.1 |
| Coordinates | 2092214..2092639 (+) | Length | 142 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A5P9XRU0 |
| Locus tag | GCD22_RS11075 | Protein ID | WP_031575119.1 |
| Coordinates | 2091960..2092217 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GCD22_RS11015 | 2087015..2087536 | + | 522 | WP_029316177.1 | hypothetical protein | - |
| GCD22_RS11020 | 2087684..2087803 | + | 120 | Protein_2139 | IS630 family transposase | - |
| GCD22_RS11025 | 2087796..2087963 | - | 168 | Protein_2140 | glycosyltransferase family 1 protein | - |
| GCD22_RS18015 | 2088009..2088389 | - | 381 | WP_051690744.1 | hypothetical protein | - |
| GCD22_RS11030 | 2088370..2088618 | - | 249 | WP_031575143.1 | hypothetical protein | - |
| GCD22_RS11035 | 2088734..2088898 | - | 165 | WP_031575140.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| GCD22_RS11040 | 2089069..2089308 | + | 240 | WP_031575137.1 | ribbon-helix-helix domain-containing protein | - |
| GCD22_RS11045 | 2089308..2089727 | + | 420 | WP_031575135.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| GCD22_RS11050 | 2089924..2090262 | + | 339 | WP_031575132.1 | winged helix DNA-binding protein | - |
| GCD22_RS11055 | 2090481..2090780 | + | 300 | WP_193354192.1 | type II toxin-antitoxin system VapC family toxin | - |
| GCD22_RS11060 | 2090784..2091014 | + | 231 | WP_010639844.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GCD22_RS11065 | 2091108..2091464 | - | 357 | WP_031575126.1 | PilT-like protein | - |
| GCD22_RS11070 | 2091486..2091737 | - | 252 | WP_031575123.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GCD22_RS11075 | 2091960..2092217 | + | 258 | WP_031575119.1 | Arc family DNA-binding protein | Antitoxin |
| GCD22_RS11080 | 2092214..2092639 | + | 426 | WP_031575116.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| GCD22_RS11085 | 2092925..2094484 | - | 1560 | WP_031575114.1 | glycosyltransferase family 4 protein | - |
| GCD22_RS11090 | 2094525..2096357 | - | 1833 | WP_140391083.1 | HAD-IIIC family phosphatase | - |
| GCD22_RS11095 | 2096528..2097283 | - | 756 | WP_031575105.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 15352.81 Da Isoelectric Point: 5.1765
>T142146 WP_031575116.1 NZ_CP045571:2092214-2092639 [Acidithiobacillus thiooxidans ATCC 19377]
IILLDTNVISETQRQEPQARVLDWLDAQALETLYLSAITVAELRAGVALMPVGKRRISLHENLEKRLLPMFANRVLSFDM
TCTKAYTELLVKSRAAGLAVETAAAFIAAVALANGFAVATRDTTPFEAAGLNVINPWEAVQ
IILLDTNVISETQRQEPQARVLDWLDAQALETLYLSAITVAELRAGVALMPVGKRRISLHENLEKRLLPMFANRVLSFDM
TCTKAYTELLVKSRAAGLAVETAAAFIAAVALANGFAVATRDTTPFEAAGLNVINPWEAVQ
Download Length: 426 bp
>T142146 NZ_CP060414:c1164439-1164257 [Neisseria musculi]
GTGAAATACAGCGAGTTCCGAAAATGGCTGCTCTCTCAGGGTGTAGAGTTTACCACGCAGAAACGCGGCAGCCACCAACT
CATCAGATTAGGTAATAAAACATCGGTTTTCCCGAACCACGGCAGTAAAGAAATCGGTACGGGATTGGTTTTGAAAATCA
AAAAAGACTTAGGTCTCAAATAA
GTGAAATACAGCGAGTTCCGAAAATGGCTGCTCTCTCAGGGTGTAGAGTTTACCACGCAGAAACGCGGCAGCCACCAACT
CATCAGATTAGGTAATAAAACATCGGTTTTCCCGAACCACGGCAGTAAAGAAATCGGTACGGGATTGGTTTTGAAAATCA
AAAAAGACTTAGGTCTCAAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9420.62 Da Isoelectric Point: 7.3223
>AT142146 WP_031575119.1 NZ_CP045571:2091960-2092217 [Acidithiobacillus thiooxidans ATCC 19377]
MANVNVRNLPDEVHRAIRIQAAHHGRSTEAEIRDILERAAKPEGRVKLGSFLASMARETGGLTDEEVALFENARIQSPAR
AARFE
MANVNVRNLPDEVHRAIRIQAAHHGRSTEAEIRDILERAAKPEGRVKLGSFLASMARETGGLTDEEVALFENARIQSPAR
AARFE
Download Length: 258 bp
>AT142146 NZ_CP060414:c1164196-1163780 [Neisseria musculi]
ATGTTGGCTTATCGCTATATTTTGACCCCCGACGACAACGGCACGCTGTTGGTAACGTTTCCCGATATTCCCGAGGCGGT
GGCAGTGGGCGAAGACGAAGAATCAGCCAAAATCGAAGCTGTTGACGGCCTGATTTGTGCTTTGGAAGGCTATTTTGAAG
ACCGCCGTGAAATTCCGCTGCCGTCTGAAAACGATGGTTCTCAAACAGTAGAACTGCCTGCGCTGGAAACGGCAAAGGTG
CTGCTGCTGAATGAAATGTTGCGCCAAAACGTGAAAAAAGCGGAAATGGCACGCCGCTTGGATGTACATATGCCGCAGAT
TGACCGCCTGCTTGATTTGCGCCACAATACGAAAATCGATTTTTTGGAAAAAGCAGCCGGAAAACTCGGCAAGCGTTTGA
ATATCAGCTTTTCTTAA
ATGTTGGCTTATCGCTATATTTTGACCCCCGACGACAACGGCACGCTGTTGGTAACGTTTCCCGATATTCCCGAGGCGGT
GGCAGTGGGCGAAGACGAAGAATCAGCCAAAATCGAAGCTGTTGACGGCCTGATTTGTGCTTTGGAAGGCTATTTTGAAG
ACCGCCGTGAAATTCCGCTGCCGTCTGAAAACGATGGTTCTCAAACAGTAGAACTGCCTGCGCTGGAAACGGCAAAGGTG
CTGCTGCTGAATGAAATGTTGCGCCAAAACGTGAAAAAAGCGGAAATGGCACGCCGCTTGGATGTACATATGCCGCAGAT
TGACCGCCTGCTTGATTTGCGCCACAATACGAAAATCGATTTTTTGGAAAAAGCAGCCGGAAAACTCGGCAAGCGTTTGA
ATATCAGCTTTTCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|