Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2063874..2064553 Replicon chromosome
Accession NZ_CP045571
Organism Acidithiobacillus thiooxidans ATCC 19377

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GCD22_RS10890 Protein ID WP_031575198.1
Coordinates 2064119..2064553 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GCD22_RS10885 Protein ID WP_031575201.1
Coordinates 2063874..2064119 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCD22_RS10860 2058984..2059253 + 270 WP_010638546.1 hypothetical protein -
GCD22_RS10865 2059323..2060138 + 816 WP_031575212.1 outer membrane protein assembly factor BamD -
GCD22_RS10870 2060157..2061002 - 846 WP_202806245.1 EamA family transporter -
GCD22_RS10875 2061075..2062526 - 1452 WP_051690749.1 MFS transporter -
GCD22_RS10880 2062528..2063631 - 1104 WP_024894929.1 AI-2E family transporter -
GCD22_RS10885 2063874..2064119 + 246 WP_031575201.1 hypothetical protein Antitoxin
GCD22_RS10890 2064119..2064553 + 435 WP_031575198.1 PIN domain-containing protein Toxin
GCD22_RS10895 2064621..2064962 - 342 WP_031575195.1 M48 family metallopeptidase -
GCD22_RS10900 2064967..2065518 - 552 Protein_2116 type I restriction endonuclease subunit R -
GCD22_RS10905 2065515..2066015 - 501 Protein_2117 type I restriction-modification system subunit M N-terminal domain-containing protein -
GCD22_RS10915 2066399..2067052 + 654 WP_010638524.1 DUF202 domain-containing protein -
GCD22_RS10920 2067055..2067621 - 567 WP_080707869.1 DUF1643 domain-containing protein -
GCD22_RS10925 2068001..2069137 + 1137 WP_051690748.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 16071.37 Da        Isoelectric Point: 6.9256

>T142145 WP_031575198.1 NZ_CP045571:2064119-2064553 [Acidithiobacillus thiooxidans ATCC 19377]
MRALLDVNVLIALLDAAHIHHRAAHHWLAQQSDGWATCPITVNGCLRILSQPGYPGALPIADIAGRLTDATDSRSHAFWP
DSLDLLHNNSLDWTKVIGHRQITDVYLLALAVDHDGCFATFDRRIQHKVLHSAREEHLIMIPGR

Download         Length: 435 bp

>T142145 NZ_CP060414:c559106-558762 [Neisseria musculi]
ATGTATATACCGGACAAGGGCGATATTATCCATCTTCGATTTGATCCCGCATCGGGAAAAGAAATGAAAGGCGGTCATTT
TGCTTTGGTGCTGACCCCGAAAGCATTCAATAAAGCTGTAGGGCTGGTTTTTGCCTGCCCCATATCCCAAGGGCAGGCAT
CGGCGGCACGCGGTATGCTTTCTACATTGCTTGGGGCGGGGACGCACACTCAGGGCAATATTCATTGCCACCAGCTGAAA
TCGCTGGATTGGAGAGAGCGCAAAGCAGCGCTCAAAGAGAAAGTGCCTGATTATGTATTGCAGGATGTTTTATCCCGCAT
TGAGGCTATTTTGGAGCTTGATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8940.11 Da        Isoelectric Point: 5.6644

>AT142145 WP_031575201.1 NZ_CP045571:2063874-2064119 [Acidithiobacillus thiooxidans ATCC 19377]
MRTTLDIEDDVLEAARELARREHISAGAAVSRLLRVAFTGHFPISTTPPETTVVNGFRPIPANNRLVTDSLIDRLRDESG
L

Download         Length: 246 bp

>AT142145 NZ_CP060414:c559348-559106 [Neisseria musculi]
ATGAAATTGCAGAAATGGGGAAACAGCGCGGCAGTGCGCTTTCCGAAAGAGATTATCAGCCGGCTCGGGTTGGAAATCGG
CGATGAATTACAAACCGAAATTCAGGGGCAAACGATTATGATTAAAGCGGCCAAACGCCCCAAATACAAACTGTCCGACC
TGCTGGCAGAAATGCCCGAAGGCGCGCCCCGTGTCGCAGGCTGGGATGAAATGTCCGATGTCGGCAGGGAGGTGGCGAAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References