Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1815049..1815830 Replicon chromosome
Accession NZ_CP045571
Organism Acidithiobacillus thiooxidans ATCC 19377

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag GCD22_RS09615 Protein ID WP_081577381.1
Coordinates 1815333..1815830 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag GCD22_RS09610 Protein ID WP_010638966.1
Coordinates 1815049..1815336 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCD22_RS18185 1812493..1812642 - 150 Protein_1850 type II toxin-antitoxin system RelE/ParE family toxin -
GCD22_RS09590 1812642..1812908 - 267 WP_031573366.1 ribbon-helix-helix domain-containing protein -
GCD22_RS09595 1813163..1813534 + 372 WP_051690666.1 helix-turn-helix transcriptional regulator -
GCD22_RS09600 1813531..1814814 + 1284 WP_031573371.1 HipA domain-containing protein -
GCD22_RS09605 1814753..1814878 - 126 WP_080707842.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GCD22_RS09610 1815049..1815336 + 288 WP_010638966.1 DUF1778 domain-containing protein Antitoxin
GCD22_RS09615 1815333..1815830 + 498 WP_081577381.1 GNAT family N-acetyltransferase Toxin
GCD22_RS09620 1815914..1816120 - 207 WP_051690667.1 hypothetical protein -
GCD22_RS09625 1816425..1816667 - 243 WP_080707843.1 DUF1778 domain-containing protein -
GCD22_RS18190 1816764..1817084 + 321 WP_031573377.1 AAA family ATPase -
GCD22_RS18195 1817060..1817362 + 303 WP_211371662.1 ATP-binding protein -
GCD22_RS09635 1817405..1818514 - 1110 WP_031573383.1 ABC transporter permease -
GCD22_RS09640 1818514..1819629 - 1116 WP_031573385.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-145)

Antitoxin

Vibrio phage ICP1, Orf50

(12-88)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18289.89 Da        Isoelectric Point: 6.6337

>T142142 WP_081577381.1 NZ_CP045571:1815333-1815830 [Acidithiobacillus thiooxidans ATCC 19377]
MSLSAPQPLDAQHRLEDFDCGKSGLTDWLLRHARQAQGSGSARTFVVCDKTRVVGYFSLTVGQIDTLDAPERIRRGMGQY
PIPLVILACLAVDLDYQKQGIGFSLLQDAIHRALAIAEHAGIRALLTHPLDADADAFYRRFGFEPTPDDDRQLILLLKDA
RRFAG

Download         Length: 498 bp

>T142142 NZ_CP060402:c3096906-3096655 [Microbacterium sp. YJN-G]
ATGTCCATTACGGCCAGTGAGGCTCGCAAGACGCTTTTCCCGTTGATCGAGCGGGTCAATGCCGATCGAGACGCCGTGGA
GATCGTGTCCCGGAAGGGCAATGCCGTCCTGATGCCTGCCGACGAGTATGCGGCGTGGCAGGAGACGGCGTACCTGTTCC
GGTCGCCCGCGAACGCTCGCCGACTGCTCGACGCCTATGAGCGAGCGCGCGCCGGCGAAGTCGAGGAGCACGAACTCGAC
CGAGACGAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10565.04 Da        Isoelectric Point: 7.0107

>AT142142 WP_010638966.1 NZ_CP045571:1815049-1815336 [Acidithiobacillus thiooxidans ATCC 19377]
MLTTNTTTRSARLGLRATPAQETVLRRAAEVAHKSLTDFILDAAYQAAEQTLLDQRLFMVTGSQYQAILEMLDRPESDNP
GLADLFSRAPVWAKK

Download         Length: 288 bp

>AT142142 NZ_CP060402:c3096655-3096401 [Microbacterium sp. YJN-G]
ATGCGTCTCGTCTGGGACAGGTCCGCCTGGGAGGACTATGTGCACTGGCAGACGGCCGACCGGAGAGTGCTCAAACGCAT
CAACGCCCTTATCGACGCATGCCTGCGTGATCCTTTCGAAGGCATCGGCAAGCCTGAGCAGCTGAAGTATGGCGCTCAGG
GTGCCTGGTCTCGACGCATAACCGAGGAGCATCGCCTTGTCTATCTCGTCGAGCGTGATGACCTCATCGTGCTGCAGGCG
CGCTACCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References