Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1507430..1507965 Replicon chromosome
Accession NZ_CP045571
Organism Acidithiobacillus thiooxidans ATCC 19377

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GCD22_RS07935 Protein ID WP_153940915.1
Coordinates 1507430..1507753 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GCD22_RS07940 Protein ID WP_211371699.1
Coordinates 1507750..1507965 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCD22_RS07910 1503691..1504281 - 591 WP_153940595.1 pilus assembly protein PilP -
GCD22_RS07915 1504274..1504906 - 633 WP_153940596.1 type 4a pilus biogenesis protein PilO -
GCD22_RS07920 1504910..1505476 - 567 WP_153940914.1 PilN domain-containing protein -
GCD22_RS07925 1505478..1506695 - 1218 WP_153940597.1 type IV pilus assembly protein PilM -
GCD22_RS07930 1506590..1507234 - 645 WP_153940598.1 hypothetical protein -
GCD22_RS07935 1507430..1507753 - 324 WP_153940915.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GCD22_RS07940 1507750..1507965 - 216 WP_211371699.1 antitoxin MazE family protein Antitoxin
GCD22_RS07945 1508323..1508676 - 354 WP_153940600.1 hypothetical protein -
GCD22_RS07950 1508794..1509468 - 675 WP_153940601.1 hypothetical protein -
GCD22_RS07955 1509793..1510350 + 558 WP_081576904.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
GCD22_RS07960 1510360..1511010 + 651 WP_031574805.1 hypothetical protein -
GCD22_RS07965 1511027..1512301 + 1275 WP_153940602.1 type II secretion system F family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(8-70)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11607.55 Da        Isoelectric Point: 10.0946

>T142141 WP_153940915.1 NZ_CP045571:c1507753-1507430 [Acidithiobacillus thiooxidans ATCC 19377]
VKRGAVVVVALHGDYGKPRPALVVQSEAFSALSSVTVLPITSDLRDAPLYRINVEASPETGLHKPSQIMVDKSQTVPREK
IGQVVGYLDYRKMVAVNRAMALFLGFA

Download         Length: 324 bp

>T142141 NZ_CP060402:c3096655-3096401 [Microbacterium sp. YJN-G]
ATGCGTCTCGTCTGGGACAGGTCCGCCTGGGAGGACTATGTGCACTGGCAGACGGCCGACCGGAGAGTGCTCAAACGCAT
CAACGCCCTTATCGACGCATGCCTGCGTGATCCTTTCGAAGGCATCGGCAAGCCTGAGCAGCTGAAGTATGGCGCTCAGG
GTGCCTGGTCTCGACGCATAACCGAGGAGCATCGCCTTGTCTATCTCGTCGAGCGTGATGACCTCATCGTGCTGCAGGCG
CGCTACCACTACTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8235.42 Da        Isoelectric Point: 8.5675

>AT142141 WP_211371699.1 NZ_CP045571:c1507965-1507750 [Acidithiobacillus thiooxidans ATCC 19377]
VTTVHANTRVKKHRDALRAAGLRPIQIWVPDTRRPGFVEECRRQCLVLRNDPQEKEIMNWLEAAADTDGWV

Download         Length: 216 bp

>AT142141 NZ_CP060402:c3096906-3096655 [Microbacterium sp. YJN-G]
ATGTCCATTACGGCCAGTGAGGCTCGCAAGACGCTTTTCCCGTTGATCGAGCGGGTCAATGCCGATCGAGACGCCGTGGA
GATCGTGTCCCGGAAGGGCAATGCCGTCCTGATGCCTGCCGACGAGTATGCGGCGTGGCAGGAGACGGCGTACCTGTTCC
GGTCGCCCGCGAACGCTCGCCGACTGCTCGACGCCTATGAGCGAGCGCGCGCCGGCGAAGTCGAGGAGCACGAACTCGAC
CGAGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References