Detailed information of TA system TA142140

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1277608..1278209
• Replicon: chromosome
• Accession: NZ_CP045571
• Organism: Acidithiobacillus thiooxidans ATCC 19377

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GCD22_RS06540
• Protein ID: WP_081577560.1
• Coordinates: 1278012..1278209 (-)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GCD22_RS06535
• Protein ID: WP_010639110.1
• Coordinates: 1277608..1278015 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCD22_RS06525	1273704..1275395	-	1692	WP_051690456.1	glycosyltransferase family 39 protein	-
GCD22_RS06530	1275598..1277505	+	1908	WP_080707738.1	cell division protein FtsI	-
GCD22_RS06535	1277608..1278015	-	408	WP_010639110.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GCD22_RS06540	1278012..1278209	-	198	WP_081577560.1	type II toxin-antitoxin system HicA family toxin	Toxin
GCD22_RS06545	1278354..1278824	-	471	WP_024893737.1	transcriptional repressor	-
GCD22_RS06550	1278942..1279421	+	480	WP_031569480.1	peroxiredoxin	-
GCD22_RS06555	1279418..1280827	+	1410	WP_031569481.1	PhoH family protein	-
GCD22_RS06560	1280894..1282780	+	1887	WP_081577561.1	biosynthetic arginine decarboxylase	-
GCD22_RS06565	1282784..1282948	+	165	Protein_1274	hemoglobin-like protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1283024..1284238	1214

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7186.29 Da
• Isoelectric Point: 10.4829

>T142140 WP_081577560.1 NZ_CP045571:c1278209-1278012 [Acidithiobacillus thiooxidans ATCC 19377]
MTSSELIKSLESAGWLHRSTKGSHHVYVHPDRPGHLSIPHPRKDLGTGLLHKLLKQAGLKEGNCK

Nucleotide

• Length: 198 bp

>T142140 NZ_CP060402:786160-786558 [Microbacterium sp. YJN-G]
GTGATCCTCATCGACACCTCCGCGTGGATCGATTATCTTCGCGCGGCTCGGACCGAGGCGCATTTCGAGGTTCGGTCAGT
GTTGCAGTCGGATGCTGATGTTCGGATCAGTGAGCCGATCATCATGGAGCTCGTCGCCGGGTCGAGGGGCAATGAGGTGG
GAATCGAGGCGCTGGTCGACGGGCTTCCCCTGCTTCCCATCGAGCCCGGTCTGGACTTCCGCGCAGCGGGCGAGCTGTTC
CGTGCGTCGCGTGCCAATGGACATCCGATCCGCAGCCTCGTCGACTGCCTGATCGCGGCGATCGCGATGCGGCACGGCGC
AACTCTTCTCCACAAGGATCGCGACTTCACCTTCCTCGCCGAGATCAGCCCGCTGAAGCTGCACTCGCCGTCGGCGTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14899.81 Da
• Isoelectric Point: 4.5061

>AT142140 WP_010639110.1 NZ_CP045571:c1278015-1277608 [Acidithiobacillus thiooxidans ATCC 19377]
MRYPIAIESGDETHAFGVVVPDLPGCFSAGDTLDEAIQMAKEAIELWLEVQIDESGDIPEPKAITEHQANPEFAHWIWAL
VDVDPALISDKAERVNITLPARVLRRVDEAAKSRHESRSGFLARAALATLRREAS

Nucleotide

• Length: 408 bp

>AT142140 NZ_CP060402:785942-786163 [Microbacterium sp. YJN-G]
ATGAGCCGCACGAACATCGACATCGACGATGACCTCGTGAGCGAGGTCATGCAGCGCTACAGCCTGACCACCAAGAAGGA
CGCAGTGAACTTCGCGCTGCGCCGGCTGGTCGGTGTGCCGCTGACGAAGGAGTTCCTGCTCAGCATGGAAGGCTCGGGCT
GGGACGGCGATCTCGACGAGATGCGAGATGATGCTCCCCGCGAGGCCTGGGCGCGCCAGTGA