Detailed information of TA system TA142138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 645217..645719
• Replicon: chromosome
• Accession: NZ_CP045571
• Organism: Acidithiobacillus thiooxidans ATCC 19377

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A1C2J0P1
• Locus tag: GCD22_RS03440
• Protein ID: WP_010641842.1
• Coordinates: 645217..645471 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GCD22_RS03445
• Protein ID: WP_010641843.1
• Coordinates: 645468..645719 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCD22_RS03420	640731..641993	+	1263	Protein_658	IS256 family transposase	-
GCD22_RS03425	643194..643499	-	306	WP_031575399.1	hypothetical protein	-
GCD22_RS17895	643729..643902	+	174	WP_170286687.1	hypothetical protein	-
GCD22_RS03430	643889..644419	+	531	WP_153940426.1	hypothetical protein	-
GCD22_RS03435	644701..645189	+	489	WP_140390914.1	DUF2442 domain-containing protein	-
GCD22_RS03440	645217..645471	-	255	WP_010641842.1	Txe/YoeB family addiction module toxin	Toxin
GCD22_RS03445	645468..645719	-	252	WP_010641843.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GCD22_RS03450	645862..647922	-	2061	WP_081576824.1	transglycosylase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	640731..641867	1136

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10310.80 Da
• Isoelectric Point: 9.5615

>T142138 WP_010641842.1 NZ_CP045571:c645471-645217 [Acidithiobacillus thiooxidans ATCC 19377]
VKLVFADETWEDYLFWQKQDRKMIERINKLIRETQREPFGGIGKPEPLKHAFSGFWSRRITDEHRMVYRVEGDQLQIAQL
RFHY

Nucleotide

• Length: 255 bp

>T142138 NZ_CP060401:c4255831-4255577 [Xenorhabdus nematophila]
ATGATTCTATCTTGGGCAGAAACGGCGTGGGAAGATTATCTTTATTGGCAACAAACCGATAAAAAAACCCTAAAACGCAT
TAATACTCTTATTAAGGATATTGCCCGACAGTCTTTTGATGGGCTAGGTGATCCTGAACCCTTAAAACATAACTGGTCAG
GATACTGGTCCAGGCGGATTGATCGTGAGCATCGCCTAGTTTATAAGGTTACAGACACCGCAATAATTATTGTTCAATGT
CGCTATCACTACTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8977.39 Da
• Isoelectric Point: 6.9752

>AT142138 WP_010641843.1 NZ_CP045571:c645719-645468 [Acidithiobacillus thiooxidans ATCC 19377]
VDAITYTKVRANLASAMDRVCDDHEALIITRNGEQSVVMLSLADYKALEETAYLLRTPANAKRLLAAAAQLNAGKGVELK
LSM

Nucleotide

• Length: 252 bp

>AT142138 NZ_CP060401:c4256082-4255828 [Xenorhabdus nematophila]
ATGAATGTTATGAGCTATTCAGCATTTCGAACTCATTTAGCTAAAACTCTGGATAAAGTGAACGATGACCACCAACCCGT
GATGATCACTCGTCAGAATGGTAAGCCAGCAGTTGTACTCAGTTTGGAGGATTTTCGGGCTTATGAAGAAACTGCCTATT
TGATGGCAAGCCCTAAAAATGCAGCGCGCCTAAACCAAGCTATTGCAGAGGTAGAAAATGGTAAAACTCTTGAAAAAGAC
TTACTGGAAGAATGA

Structures

Toxin

• AlphaFold DB: A0A1C2J0P1