Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 577378..577979 Replicon chromosome
Accession NZ_CP045571
Organism Acidithiobacillus thiooxidans ATCC 19377

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GCD22_RS03105 Protein ID WP_153940389.1
Coordinates 577782..577979 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GCD22_RS03100 Protein ID WP_153940388.1
Coordinates 577378..577785 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCD22_RS03070 572923..574473 + 1551 WP_153940899.1 relaxase/mobilization nuclease domain-containing protein -
GCD22_RS03075 574753..575049 + 297 WP_153940384.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCD22_RS03080 575053..575352 + 300 WP_012536655.1 putative addiction module antidote protein -
GCD22_RS03085 575452..575766 + 315 WP_153940385.1 hypothetical protein -
GCD22_RS03090 575918..576370 + 453 WP_153940386.1 hypothetical protein -
GCD22_RS03095 576367..577335 + 969 WP_153940387.1 P-type conjugative transfer ATPase TrbB -
GCD22_RS03100 577378..577785 - 408 WP_153940388.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GCD22_RS03105 577782..577979 - 198 WP_153940389.1 type II toxin-antitoxin system HicA family toxin Toxin
GCD22_RS03110 578261..578647 + 387 WP_153940390.1 TrbC/VirB2 family protein -
GCD22_RS03115 578651..579028 + 378 WP_153940391.1 VirB3 family type IV secretion system protein -
GCD22_RS03120 579028..581562 + 2535 WP_153940392.1 conjugal transfer protein TrbE -
GCD22_RS03125 581565..581795 + 231 Protein_603 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 543342..644627 101285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7183.31 Da        Isoelectric Point: 9.8602

>T142137 WP_153940389.1 NZ_CP045571:c577979-577782 [Acidithiobacillus thiooxidans ATCC 19377]
MTSSELIKCLESAGWLHRSTKGSHHVYVHPDHPGHLSIPHPRKDLGTGLLHKLLKQAGLKEGNCK

Download         Length: 198 bp

>T142137 NZ_CP060401:4234436-4234744 [Xenorhabdus nematophila]
ATGCAATTTTTTGTTTATCAATACAAACGTAGTGGAAGTAAATACAGCATGTTTGTCGATGTCCAGAGTGATATCATTGA
AACATTAGGAAGGCGGATCGTTATTCCTTTGATTGAAGCAAATCATTTCTCAAATAAAGTCAATCGTCAGTTATTCCCTG
TAGTGCAACTCAGAGGTGAGAATTACCGGCTTTTAACAACTGAAATTTCAGGTGTGGCTGAAAGTGTCATAGGTCACGAA
ATTGCTGATGTAAACCCATTCTCATCAGATATTAAGAACGCGCTTAATATCTTGTTTTGGGGCGTTTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14957.85 Da        Isoelectric Point: 4.4429

>AT142137 WP_153940388.1 NZ_CP045571:c577785-577378 [Acidithiobacillus thiooxidans ATCC 19377]
MRYPIAIESEDETHAFGVVVPDLPGCFSAGDTLDEAIQMAKEAIELWLEVQIDEGGDIPEPKSITEHQANPEFAHWIWAL
VDVDPAILSDKAERVNITLPARVLRRVDEAAKSRHESRSGFLARAALATLRREAS

Download         Length: 408 bp

>AT142137 NZ_CP060401:4234217-4234435 [Xenorhabdus nematophila]
ATGAAACATAGAGTTAATGTAACAGTTGATAAAGAGAATTATCTCATCCTGAGTTCTGCCGGGGTCAATATTTCAGGTTT
TGTTAATGAGCTCATGAGCAAGGAAGCTCAACGTATCAAAGCCGAGAATTGGAAAAAAGATAATTTGGAAGGCATGGAAG
AAGTGGCTCAATTTATCAAACAGCATGGTTCATTTGCTGATGAAAACAGGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References