142128

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1269513..1270164 Replicon chromosome
Accession NZ_CP045560
Organism Acinetobacter nosocomialis strain AC1530

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Q0RPK1
Locus tag GD578_RS06160 Protein ID WP_000838147.1
Coordinates 1269513..1269695 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L9LVK3
Locus tag GD578_RS06165 Protein ID WP_002053018.1
Coordinates 1269760..1270164 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD578_RS06115 1264766..1265431 + 666 WP_086610766.1 stress-responsive nuclear envelope protein -
GD578_RS06120 1265436..1265825 + 390 WP_020752393.1 hypothetical protein -
GD578_RS06125 1265827..1266195 + 369 WP_202981979.1 glutamate 5-kinase -
GD578_RS06130 1266204..1266616 + 413 Protein_1178 hypothetical protein -
GD578_RS06135 1266582..1266950 + 369 WP_001983390.1 hypothetical protein -
GD578_RS06140 1266952..1267350 + 399 WP_153518342.1 hypothetical protein -
GD578_RS06145 1267352..1267564 + 213 WP_002053072.1 hypothetical protein -
GD578_RS06150 1267671..1268600 + 930 WP_002053038.1 hypothetical protein -
GD578_RS06155 1268648..1269181 + 534 WP_001185621.1 hypothetical protein -
GD578_RS06160 1269513..1269695 + 183 WP_000838147.1 type II toxin-antitoxin system HicA family toxin Toxin
GD578_RS06165 1269760..1270164 + 405 WP_002053018.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GD578_RS06170 1270263..1270439 + 177 WP_074031683.1 hypothetical protein -
GD578_RS06175 1270448..1270771 + 324 WP_000523929.1 DUF4236 domain-containing protein -
GD578_RS06180 1270805..1271338 + 534 WP_000719143.1 hypothetical protein -
GD578_RS06185 1271350..1271751 + 402 WP_000758222.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1176705..1292442 115737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.88 Da        Isoelectric Point: 10.6602

>T142128 WP_000838147.1 NZ_CP045560:1269513-1269695 [Acinetobacter nosocomialis]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Download         Length: 183 bp

>T142128 NZ_CP060401:3235419-3236318 [Xenorhabdus nematophila]
ATGTTGCCTGTTGTAGCTCAAGAGAAAATGTTTGCACTAAAAGGTGGGACAGCTATCAACCTGTTTGTACGTGAATTCCC
TCGTCTGTCTGTGGATATCGACTTGGCATATTTACCATTAGAACCAAGAGATGTAGCGTTGGTGAATGTCCGTGCTGCGC
TACAACGCATTGTCGACAATATTAATGTTCAACCCAATGTCACAGCGATTTTACAAGATAACAAAACCGATGAACTTCGT
ATTGTTATTTCCAATAACAATGCCACCATTAAAATAGAAATTTCTCCGGTTGCACGAGGTACCTTACACAAACCAGAAGA
TAGAGCGGTTGTTGAATTTGTGGAGGATGAATTTGGCTATGCTGAAATTTCAGTAGTCAGTTTGCCTGATCTTTATGGTG
GAAAAATTTGCGCTGCGATGGACAGGCAACATCCGAGGGATCTGTTCGATGTGAAGATGCTCTTAAACGAAGAAGGTATT
TCACGAGATATCTTTATAGGTTTTTTAACTTACGCACTGAGTCATAAAAGGCCAATTAACGAAATAATGGCCCCAAACTG
GCAATCAATGGGCGAGAAATTCTCTCGCGAGTTCGAGGGAATGACACTTGAACAGGTTGAGCTGGCAGAACTGGAAGCAA
TCCGCTTCGAAATGCTTGCTGAGTTACAAAAACATCTAACTGAAAAAGACCGTCACTTTTTGCTGTCGTTTAAACGAGGA
GAACCTGATTGGGCACTGTTTGATGCACTTTCTGCTGCCGATTTACCCGCTATTCGTTGGAAGTTACTCAACATTGAAAC
GCTAAAAACAAAAAATCCGGATAAGCATCAAGAGCAACTGAAAAAACTTGAGCAAGTGTTAGATCAATGGTTAAAAAAAG
CCGAACTTAATTCTCAATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14660.69 Da        Isoelectric Point: 4.4289

>AT142128 WP_002053018.1 NZ_CP045560:1269760-1270164 [Acinetobacter nosocomialis]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT142128 NZ_CP060401:3234580-3235356 [Xenorhabdus nematophila]
ATGAACTCAAAAATAAACTGGTTAGTAAATCATACAACGCCTGGCTCACTGGTTCTGCAACAGTGGCTGGTTGAAAATGG
TATCAGCCACTCCCTGACTCAAAAGTACGCTCAGAATGGTTGGTTAAAAAAGCTGTTCACTGGTGTCTACTATCGTCCCG
ATCCAATAAAAAATCATATACCGAATTGGGCTGATGCACTGCAAGCTTTAGCTGATCAAATTCATTTACAGATTCATATT
TCCGGTTTAACTAGTTTGACTCATCAAGGACTTAGCCATTATTTGCCTCTGAAATCAGAAAAGGTATGGATAGGAGTGAG
AAATAAACAATCTCTTCCTAAGTGGTTTAAAGAGTTTCCCAACCAAAACTGGCAGTATTGCAACAACAGTAAACTGAGAG
AATTGTCAGACAAAGATTTCACAATCGTTCTGGTCAATGGAAAAGAACTCAAAGCGAGTACACCGGAACTGGCAGCTTAT
GAAGCCGTCGATTCAATTGGCAAACACATTAGCTTTGAGCACACTGCTGAGCTGTTTCAGGGACTGGTCAATTTGAGCCC
CCGAAAAGTGCAGTCATTACTCAATCGCAGCAAAGCTGTTCAAACCAACCGCATTTTCCTTTATCTAAGCCACTATCACG
ATCACCAGTGGGTAAAACGCCTTGATGAGTCACAGATTGAACTAGGCTCAGGTAAGCGCCAAGTTGTGACCCAAGGACGG
TATGACGAACGCTATAAAATCACGATTCCTGAATCTTTAATTCCTAAAAGCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q0RPK1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q0RVR6

References