Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3734230..3735113 Replicon chromosome
Accession NZ_CP045553
Organism Pseudomonas sp. 13159349

Toxin (Protein)


Gene name - Uniprot ID A0A0P7D1P0
Locus tag GEV38_RS17285 Protein ID WP_054572085.1
Coordinates 3734230..3734667 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID F8G488
Locus tag GEV38_RS17290 Protein ID WP_013973163.1
Coordinates 3734664..3735113 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEV38_RS17265 3729396..3730460 + 1065 WP_015270847.1 TerC family protein -
GEV38_RS17270 3730600..3731829 - 1230 WP_054572083.1 acyl-CoA dehydrogenase -
GEV38_RS17275 3731970..3732896 + 927 WP_015270849.1 LysR family transcriptional regulator -
GEV38_RS17280 3733068..3734222 + 1155 WP_054572084.1 aminotransferase class V-fold PLP-dependent enzyme -
GEV38_RS17285 3734230..3734667 - 438 WP_054572085.1 RES family NAD+ phosphorylase Toxin
GEV38_RS17290 3734664..3735113 - 450 WP_013973163.1 DUF2384 domain-containing protein Antitoxin
GEV38_RS17295 3735212..3735865 - 654 WP_054572086.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
GEV38_RS17300 3735970..3736893 + 924 WP_054572087.1 LysR family transcriptional regulator -
GEV38_RS17305 3736941..3737771 + 831 WP_015270854.1 AraC family transcriptional regulator -
GEV38_RS17310 3737822..3738406 + 585 WP_054572088.1 LysE family translocator -
GEV38_RS17315 3738546..3739745 - 1200 WP_054572089.1 sugar transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-132)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15985.23 Da        Isoelectric Point: 5.1199

>T142124 WP_054572085.1 NZ_CP045553:c3734667-3734230 [Pseudomonas sp. 13159349]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPAGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSSQTELTRGLGNRFLDECSALLLPVPSAIMPSTTNYLFNPRHLQANSARLEVEDFTPDSRLF

Download         Length: 438 bp

>T142124 NZ_CP060401:c2593700-2593497 [Xenorhabdus nematophila]
ATGACTAAAACTGACTATCTGATGCGTTTGAGAAAATGCACTTCTATTGAAACACTGGAACGTGTAATTGAAAAAAATAA
ATATGAACTTTCGGATGATGAACTTGAATTGTTCTACTCCGCTGCTGACCACCGTTTAGCCGAACTTACCATGAATAAAC
TCTATGATAAAATCCCATCATCTGTTTGGAAATTCGTCCGCTAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 17004.59 Da        Isoelectric Point: 6.3405

>AT142124 WP_013973163.1 NZ_CP045553:c3735113-3734664 [Pseudomonas sp. 13159349]
MLAEVLRDNGYHEYRARLHALLEIPELASDFEIHTRITHGFAATWLVKLTELGVFTPVERDQIIPLRTLKTRIERDQPLT
VEESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGFGL

Download         Length: 450 bp

>AT142124 NZ_CP060401:c2594115-2593747 [Xenorhabdus nematophila]
ATGGATGAATATTCACCAAAAAGATATGATATCGCTGAATTAAAATACTTGTGTGAAAAATTAATTCATGAGGCACTTTC
AGTCCTGAATCGCGCTGATAGTCACTGGATTCACGATCTGACTTCCGAGAAAAGCTTAAAATTAAACGAATTGATCGAAC
ACATTGCAGCTTTTGTCTGGAACTTTAAAATTAAATACACTGATCACTACGATCTCAGCACCTTAATTGATGAGTATCTG
GATGAAACATATAATTTGTTTGGAAGCGATAAGATAAGCTTTCTTGAACTTACTAAATGGCAAAGAACAAACGAACACTT
AACTAACATTCTGCTACATGATTTGAATGCTTCTTTAAGTAAAACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7D1P0

Antitoxin

Source ID Structure
AlphaFold DB F8G488

References