Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2379913..2380429 Replicon chromosome
Accession NZ_CP045553
Organism Pseudomonas sp. 13159349

Toxin (Protein)


Gene name relE Uniprot ID F8G1E7
Locus tag GEV38_RS11250 Protein ID WP_003259987.1
Coordinates 2380148..2380429 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8G1E6
Locus tag GEV38_RS11245 Protein ID WP_013972043.1
Coordinates 2379913..2380158 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEV38_RS11225 2375325..2375804 - 480 WP_015269934.1 transposase -
GEV38_RS11230 2376061..2376603 - 543 WP_054572953.1 WYL domain-containing protein -
GEV38_RS11235 2377339..2378532 + 1194 WP_015269936.1 MFS transporter -
GEV38_RS11240 2378563..2379669 + 1107 WP_054572951.1 alkene reductase -
GEV38_RS11245 2379913..2380158 + 246 WP_013972043.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GEV38_RS11250 2380148..2380429 + 282 WP_003259987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GEV38_RS11255 2380445..2381077 - 633 WP_015269938.1 BRCT domain-containing protein -
GEV38_RS11260 2381094..2381489 - 396 WP_023662326.1 hypothetical protein -
GEV38_RS11265 2381578..2382486 - 909 WP_013972045.1 LysR family transcriptional regulator -
GEV38_RS11270 2382778..2384082 + 1305 WP_013972046.1 MHS family MFS transporter -
GEV38_RS11275 2384113..2385354 + 1242 WP_015269941.1 Zn-dependent hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-76)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10909.78 Da        Isoelectric Point: 10.7594

>T142123 WP_003259987.1 NZ_CP045553:2380148-2380429 [Pseudomonas sp. 13159349]
MTYKLEFLPSALKEWGKLGHTVREQIKKKLAERLQSPKVQADALRDLPNHYKIKLKASGYRLVYRVEDERIVVVVVSVGK
RERSEVYRSAQKR

Download         Length: 282 bp

>T142123 NZ_CP060401:c1993253-1993080 [Xenorhabdus nematophila]
ATGATATTTAATATCGAGTTTGACGAACGCGCTGGAAAAGAATGGCAAAAGCTGGATAACAGCATTCGTGAACAGTTTAA
AAAGAAGCTGAAAAAGTTACAGAAAAACCCTTATATCGAGCCTGCCAGACTACATGGCGATTTAGCGTGTTTTCTGAGGA
ATTTTTCTTTTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8779.21 Da        Isoelectric Point: 4.3611

>AT142123 WP_013972043.1 NZ_CP045553:2379913-2380158 [Pseudomonas sp. 13159349]
MQNIFADVAVSVSELKKNPSAVMTGAAGMPVAVLNHNRVMGYMVPAELYEAMMERLEDLELSELAKSRLGEKGVPVSLDD
L

Download         Length: 246 bp

>AT142123 NZ_CP060401:c1993497-1993243 [Xenorhabdus nematophila]
ATGAGCACCATCCAAATAAGAGTAGATGAAGAGCTTAAGAAAAGTGCATATCAGGCATTTGATAAGCTGAATCTGTCCCC
TTCTGATGCAATGCGACTCTTCCTGCGTTATGTGGCAGAACATGAAAAGCTACCATTTACTGAGGTATCGGTGATGGTTG
CAGAGCACGATGAAGATGAAGATATTCTGGATGTAGTACGCGATCGCCTAAAGAATCCTGCCAAACGAATCCGGGTAAAT
CTCGATGATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8G1E7

Antitoxin

Source ID Structure
AlphaFold DB F8G1E6

References